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Cat.No. 0879 - Palmitoylethanolamide | C18H37NO2 | CAS No. 544-31-0
Description: Selective GPR55 agonist. FAAH and PAA substrate
Alternative Names: PEA
Chemical Name: N-(2-Hydroxyethyl)hexadecanamide
Citations (10)
Literature (3)

Biological Activity for Palmitoylethanolamide

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.

Technical Data for Palmitoylethanolamide

M. Wt 299.5
Formula C18H37NO2
Storage Store at RT
CAS Number 544-31-0
PubChem ID 4671

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Palmitoylethanolamide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.99 20
ethanol 7.49 25

Preparing Stock Solutions for Palmitoylethanolamide

The following data is based on the product molecular weight 299.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.36 mL 66.78 mL 133.56 mL
1.25 mM 2.67 mL 13.36 mL 26.71 mL
2.5 mM 1.34 mL 6.68 mL 13.36 mL
12.5 mM 0.27 mL 1.34 mL 2.67 mL

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Product Datasheets for Palmitoylethanolamide

Certificate of Analysis / Product Datasheet
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References for Palmitoylethanolamide

References are publications that support the biological activity of the product.

Lambert et al (2001) Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 42 321 PMID: 11442148

Lambert et al (2002) The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 9 663 PMID: 11945130

Lo Verme et al (2005) The search for the palmitoylethanolamide receptor. Life Sci. 77 1685 PMID: 15963531

Re et al (2005) Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 173 21 PMID: 16324856

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

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Keywords: Palmitoylethanolamide, Palmitoylethanolamide supplier, Endogenous, lipid, PPARα, PPARalpha, agonists, activity, Selective, GPR55, FAAH, PAA, PEA-preferring, acid, amidase, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoid, Anandamide, Fatty, Acid, Amide, Hydrolases, PEA, Hydrolase, (FAAH), Other, Cannabinoids, 0879, Tocris Bioscience

10 Citations for Palmitoylethanolamide

Citations are publications that use Tocris products. Selected citations for Palmitoylethanolamide include:

Nieri et al (2006) Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol 148 682 PMID: 16715117

Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174

Redlich et al (2014) Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. PLoS One 11 108 PMID: 24927796

Maingret et al (2001) The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J 20 47 PMID: 11226154

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Literature in this Area

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