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Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)|
References are publications that support the biological activity of the product.
Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937 PMID: 8083191
Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167 PMID: 19059366
Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619 PMID: 8195210
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Keywords: AACOCF3, AACOCF3 supplier, FAAH, inhibitors, inhibits, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors, Arachidonyl, trifluoromethyl, ketone, Other, Hydrolase, (FAAH), 1462, Tocris Bioscience
5 Citations for AACOCF3
Citations are publications that use Tocris products. Selected citations for AACOCF3 include:
Bianca et al (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110 15812 PMID: 24019484
Schattauer et al (2017) Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nat Commun 8 743 PMID: 28963507
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
Wang et al (2016) The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. PLoS Pathog. 12 e1005803 PMID: 27482714
Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Int J Obes (Lond) 35 4552 PMID: 25788673
Do you know of a great paper that uses AACOCF3 from Tocris? Please let us know.
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Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
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