AACOCF3

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Cat.No. 1462 - AACOCF3 | C21H31F3O | CAS No. 149301-79-1
Description: Phospholipase A2 inhibitor
Alternative Names: Arachidonyl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
Datasheet
Citations (3)
Literature

Biological Activity

Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.

Technical Data

M. Wt 356.47
Formula C21H31F3O
Storage Desiccate at -20°C
CAS Number 149301-79-1
PubChem ID 5280436
InChI Key PLWROONZUDKYKG-DOFZRALJSA-N
Smiles O=C(C(F)(F)F)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 356.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.05 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937 PMID: 8083191

Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167 PMID: 19059366

Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619 PMID: 8195210


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Keywords: FAAH inhibitors inhibits Phospholipases A2 Anandamide Amidase Fatty Acid Amide Hydrolases PLA2 Esterases Cannabinoids Receptors Arachidonyl trifluoromethyl ketone Phospholipases

3 Citations for AACOCF3

Citations are publications that use Tocris products. Selected citations for AACOCF3 include:

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Int J Obes (Lond) 35 4552 PMID: 25788673

Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815

Bianca et al (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110 15812 PMID: 24019484


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