Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAACOCF3
Description: Phospholipase A2 inhibitor
Alternative Names: Arachidonyl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
Biological Activity
Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.
Technical Data
| M. Wt | 356.47 |
| Formula | C21H31F3O |
| Storage | Desiccate at -20°C |
| CAS Number | 149301-79-1 |
| PubChem ID | 5280436 |
| InChI Key | PLWROONZUDKYKG-DOFZRALJSA-N |
| Smiles | O=C(C(F)(F)F)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
Product Datasheets
References
References are publications that support the biological activity of the product.
Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937 PMID: 8083191
Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167 PMID: 19059366
Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619 PMID: 8195210
If you know of a relevant reference for AACOCF3, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AACOCF3, AACOCF3 supplier, FAAH, inhibitors, inhibits, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors, Arachidonyl, trifluoromethyl, ketone, Other, Hydrolase, (FAAH), 1462, Tocris Bioscience
5 Citations for AACOCF3
Citations are publications that use Tocris products. Selected citations for AACOCF3 include:
Schattauer et al (2017) Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nat Commun 8 743 PMID: 28963507
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
Wang et al (2016) The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. PLoS Pathog. 12 e1005803 PMID: 27482714
Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Int J Obes (Lond) 35 4552 PMID: 25788673
Bianca et al (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110 15812 PMID: 24019484
Do you know of a great paper that uses AACOCF3 from Tocris? Please let us know.
Reviews for AACOCF3
Average Rating: 5 (Based on 1 Review.)
Have you used AACOCF3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
used this drug as an inhibitor.
By
Eric Wang on 10/05/2017
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophages
Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Asthma Poster
Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.