Cannabinoid Transporters

Cannabinoid transporters, often referred to as anandamide membrane transporters (AMTs), uptake endocannabinoids and limit their activity at CB1, CB2 and GPR55 receptors. They facilitate endocannabinoid breakdown by internalizing the molecule.

Products
Background
Literature

Inhibitors

Cat No Product Name / Activity
3381 AM 1172
Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist
1116 AM 404
Anandamide transport inhibitor
1354 Arvanil
Potent CB1 and TRPV1 (VR1) agonist/anandamide transport inhibitor
1570 (-)-Cannabidiol
Natural cannabinoid; AMT inhibitor, GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist
1481 (-)-5'-DMH-CBD
Metabolically stable anandamide transport inhibitor
2452 LY 2183240
Novel, potent anandamide uptake inhibitor; inhibits FAAH
1446 O-2093
Inhibitor of anandamide uptake
1797 OMDM-2
Potent inhibitor of anandamide uptake
1966 UCM 707
Potent anandamide transport inhibitor
1392 VDM 11
Potent, selective anandamide transport inhibitor
1686 VDM 11 (in Tocrisolve™ 100)
Potent, selective anandamide transport inhibitor (in water-soluble emulsion)

Cannabinoid transporters, often referred to as anandamide membrane transporters (AMTs), uptake endocannabinoids and limit their activity at CB1, CB2 and GPR55 receptors. Cannabinoid transporters facilitate endocannabinoid breakdown by internalizing the molecule and allowing access to fatty acid amide hydrolase (FAAH).

As endocannabinoids are widely distributed, it has been suggested that AMTs are also found in many different tissues, although this is as yet unverified. The cannabinoid transporter is thought to play a vital role in the endocannabinoid system, but currently little is known about it and the gene encoding this protein is uncharacterized.

Literature for Cannabinoid Transporters

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.