Lipases

Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3752 GSK 264220A
Endothelial lipase and lipoprotein lipase inhibitor
3540 Orlistat
Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity
1842 RHC 80267
Diacylglycerol lipase inhibitor
5839 XEN 445
Selective endothelial lipase inhibitor; orally bioavailable

Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. This is a diverse class of enzymes and includes diacylglycerol lipase and lipoprotein lipase (E.C. 3.1.1.34), and endothelial lipase (E.C. 3.1.1.3).

Diacylglycerol lipase (DAGL) catalyzes the conversion of 1,2,diacylglycerol (DAG) into the endocannabinol, 2'arachidonylglycerol (2'AG). 2'AG is a cannabinoid receptor 1 (CB1) agonist and is involved in the inhibition of neurotransmitter release. There are two DAGL isoforms; DAGLα and DAGLβ. Both isoforms are associated with the plasma membrane and are stimulated by Ca2+. They are found throughout the central nervous system, where they appear to be targeted exclusively to post-synaptic neuronal membranes.

Endothelial lipase (LIPG) is a vascular lipase which is synthesized in endothelial cells. LIPG hydrolyzes the phospholipids of VLDL, chylomicrons and HDL; it also displays triglyceride lipase activity.

Lipoprotein lipase (LPL), like LIPG, is a vascular lipase, however it is not synthesized in endothelial cells. It is anchored to the capillary endothelium by proteoglycans and catalyzes the hydrolysis of triglycerides to release free fatty acids into the circulation. LPL therefore initiates the processing of triglyceride-rich lipoproteins such as chylomicrons and VLDL.

Literature for Lipases

Cancer

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Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

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Lipase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
DAGLα Human DAGLA NM_006133 Q9Y4D2
Mouse Dagla NM_198114 Q6WQJ1
Rat Dagla NM_001005886 Q5YLM1
DAGLβ Human DAGLB NM_139179 Q8NCG7
Mouse Daglb NM_144915 Q91WC9
Rat Daglb NM_001107120 P0C1S9
MAGL Human MGLL NM_007283 Q99685
Mouse Mgll NM_011844 O35678
Rat Mgll NM_138502 Q8R431
LIPG Human LIPG NM_006033 AF118767
Mouse Lipg NM_010720 Q9WVG5
Rat Lipg NM_001012741 Q8VBX1
LPL Human LPL NM_000237 Q71UV2
Mouse Lpl NM_008509 P11152
Rat Lpl NM_012598 Q06000