TC-F 2

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Cat.No. 4355 - TC-F 2 | C26H25N5O2 | CAS No. 1304778-15-1
Description: Potent, reversible and selective FAAH inhibitor
Chemical Name: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC50 > 20 μM for CB1, CB2 and TRPV1). Active in vivo.

Compound Libraries

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Technical Data

M. Wt 439.51
Formula C26H25N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1304778-15-1
PubChem ID 25198728
InChI Key NXTBLPPTZRPJCA-IBGZPJMESA-N
Smiles O=C(N(CC)C6=C5C=CC=C6)N5[C@H]1CCCN(C2=NC(C3=CC(C=CC=C4)=C4O3)=CC=N2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 439.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.38 mL 22.75 mL
5 mM 0.46 mL 2.28 mL 4.55 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Min et al (2011) Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 108 7379 PMID: 21502526

Gustin et al (2011) Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 21 2492 PMID: 21392988


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View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: TC-F 2, TC-F 2 supplier, TCF2, TC-F2, fatty, acid, amide, hydrolase, FAAH, inhibits, inhibitors, reversible, noncovalent, potent, in, vivo, selective, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4355, Tocris Bioscience

Citations for TC-F 2

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