PF 04457845

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Cat.No. 6374 - PF 04457845 | C23H20F3N5O2 | CAS No. 1020315-31-4
Description: Potent and selective irreversible FAAH inhibitor
Chemical Name: N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity

Potent and selective irreversible FAAH inhibitor (IC50 = 7.2 nM). Selective for FAAH over a panel of other serine hydrolases. Exhibits efficacy in a rat inflammatory pain model. Orally bioavailable and brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries

PF 04457845 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 455.43
Formula C23H20F3N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1020315-31-4
PubChem ID 24771824
Smiles FC(F)(C1=CC=C(N=C1)OC2=CC=CC(/C=C3CCN(C(NC4=CC=CN=N4)=O)CC\3)=C2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.54 100
ethanol 9.11 20

Preparing Stock Solutions

The following data is based on the product molecular weight 455.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References are publications that support the biological activity of the product.

Ahn et al (2011) Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J.Pharmacol.Exp.Ther. 338 114 PMID: 21505060

Johnson et al (2011) Discovery of PF-04457845: a highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2 91 PMID: 21666860

If you know of a relevant reference for PF 04457845, please let us know.

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