URB 597

Pricing Availability   Qty
Description: Potent and selective FAAH inhibitor
Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Purity: ≥99% (HPLC)
Citations (6)
Literature (2)

Biological Activity for URB 597

URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Technical Data for URB 597

M. Wt 338.4
Formula C20H22N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 546141-08-6
PubChem ID 1383884
Smiles NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for URB 597

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.92 50

Preparing Stock Solutions for URB 597

The following data is based on the product molecular weight 338.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.91 mL 29.55 mL 59.1 mL
2.5 mM 1.18 mL 5.91 mL 11.82 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
25 mM 0.12 mL 0.59 mL 1.18 mL

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References for URB 597

References are publications that support the biological activity of the product.

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410

Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291

If you know of a relevant reference for URB 597, please let us know.

View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: URB 597, URB 597 supplier, URB597, faah, fatty, acid, amide, hydrolase, inhibitors, inhibits, selective, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4612, Tocris Bioscience

6 Citations for URB 597

Citations are publications that use Tocris products. Selected citations for URB 597 include:

Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59 PMID: 27553121

Marc V et al (2021) Neurexin1α differentially regulates synaptic efficacy within striatal circuits. Cell Rep 34 108773 PMID: 33626349

Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418 PMID: 25999668

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678 PMID: 24803745

Do you know of a great paper that uses URB 597 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.