URB 597

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Cat.No. 4612 - URB 597 | CAS No. 546141-08-6
Description: Potent and selective FAAH inhibitor
Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Compound Libraries

URB 597 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 338.4
Formula C20H22N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 546141-08-6
PubChem ID 1383884
InChI Key ROFVXGGUISEHAM-UHFFFAOYSA-N
Smiles NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.92 50

Preparing Stock Solutions

The following data is based on the product molecular weight 338.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410

Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291


If you know of a relevant reference for URB 597, please let us know.

View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: URB597 faah fatty acid amide hydrolase inhibitors inhibits selective potent Fatty Acid Amide Hydrolase (FAAH)

4 Citations for URB 597

Citations are publications that use Tocris products. Selected citations for URB 597 include:

Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59 PMID: 27553121

Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418 PMID: 25999668

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678 PMID: 24803745

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234


Do you know of a great paper that uses URB 597 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Pain

Pain Research Product Guide

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Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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Pathways for URB 597

Protocols

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