URB 597

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Cat.No. 4612 - URB 597 | CAS No. 546141-08-6
Description: Potent and selective FAAH inhibitor
Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (3)

Biological Activity

Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Compound Libraries

URB 597 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 338.4
Formula C20H22N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 546141-08-6
PubChem ID 1383884
InChI Key ROFVXGGUISEHAM-UHFFFAOYSA-N
Smiles NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.92 50

Preparing Stock Solutions

The following data is based on the product molecular weight 338.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.91 mL 29.55 mL 59.1 mL
2.5 mM 1.18 mL 5.91 mL 11.82 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
25 mM 0.12 mL 0.59 mL 1.18 mL

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References

References are publications that support the biological activity of the product.

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410

Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291


If you know of a relevant reference for URB 597, please let us know.

View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

Keywords: URB 597, URB 597 supplier, URB597, faah, fatty, acid, amide, hydrolase, inhibitors, inhibits, selective, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4612, Tocris Bioscience

5 Citations for URB 597

Citations are publications that use Tocris products. Selected citations for URB 597 include:

Hamtiaux et al (2012) The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer 12 92 PMID: 22429826

Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418 PMID: 25999668

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678 PMID: 24803745


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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