Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 338.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.78 mL||29.55 mL|
|5 mM||0.59 mL||2.96 mL||5.91 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410
Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756
Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291
If you know of a relevant reference for URB 597, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: URB597 faah fatty acid amide hydrolase inhibitors inhibits selective potent Fatty Acid Amide Hydrolase (FAAH)
4 Citations for URB 597
Citations are publications that use Tocris products. Selected citations for URB 597 include:
Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59 PMID: 27553121
Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418 PMID: 25999668
Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678 PMID: 24803745
Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234
Do you know of a great paper that uses URB 597 from Tocris? If so please let us know.
Literature in this Area
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.