Bupropion hydrochloride

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Cat.No. 2831 - Bupropion hydrochloride | C13H18ClNO.HCl | CAS No. 31677-93-7
Description: Non-selective inhibitor of dopamine and noradrenalin transporters
Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Compound Libraries

Bupropion hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 276.2
Formula C13H18ClNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 31677-93-7
PubChem ID 62884
InChI Key HEYVINCGKDONRU-UHFFFAOYSA-N
Smiles ClC1=CC=CC(C(C(C)NC(C)(C)C)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.62 100
ethanol 27.62 100
water 27.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Slemmer et al (2000) Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 295 321 PMID: 10991997

Torres et al (2003) Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858

Dwoskin et al (2006) Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 12 178 PMID: 17227286


If you know of a relevant reference for Bupropion hydrochloride, please let us know.

View Related Products by Product Action

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Keywords: Bupropion hydrochloride, supplier, Non-Selective, inhibitors, inhibits, dopamine, noradrenaline, transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, reuptake, Dopamine, Transporters, Tocris Bioscience

2 Citations for Bupropion hydrochloride

Citations are publications that use Tocris products. Selected citations for Bupropion hydrochloride include:

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Neuropsychopharmacology 29 15551 PMID: 20007479

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Cardiovasc Res 40 766 PMID: 25249058


Do you know of a great paper that uses Bupropion hydrochloride from Tocris? If so please let us know.

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Pathways for Bupropion hydrochloride

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