Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 276.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.62 mL||18.1 mL||36.21 mL|
|5 mM||0.72 mL||3.62 mL||7.24 mL|
|10 mM||0.36 mL||1.81 mL||3.62 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References are publications that support the products' biological activity.
Slemmer et al (2000) Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 295 321 PMID: 10991997
Torres et al (2003) Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858
Dwoskin et al (2006) Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 12 178 PMID: 17227286
If you know of a relevant reference for Bupropion hydrochloride, please let us know.
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Keywords: Bupropion hydrochloride, supplier, Non-Selective, inhibitors, inhibits, dopamine, noradrenaline, transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, reuptake, Dopamine, Transporters, Adrenergic, Transporters, Dopamine, Transporters, Tocris Bioscience
2 Citations for Bupropion hydrochloride
Citations are publications that use Tocris products. Selected citations for Bupropion hydrochloride include:
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Cardiovasc Res 40 766 PMID: 25249058
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Neuropsychopharmacology 29 15551 PMID: 20007479
Do you know of a great paper that uses Bupropion hydrochloride from Tocris? If so please let us know.
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