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Potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||3.29||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 328.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.04 mL||15.21 mL||30.43 mL|
|5 mM||0.61 mL||3.04 mL||6.09 mL|
|10 mM||0.3 mL||1.52 mL||3.04 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References are publications that support the biological activity of the product.
Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868 PMID: 11123996
Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin. J.Neurochem. 44 1615 PMID: 2580950
Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60 PMID: 10490887
If you know of a relevant reference for Indatraline hydrochloride, please let us know.
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Keywords: Indatraline hydrochloride, Indatraline hydrochloride supplier, Potent, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, 5-HT, dopamine, Noradrenalin, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-Hydroxytryptamine, Lu19-005, Lu, 19-005, 1588, Tocris Bioscience
Citations for Indatraline hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.