Indatraline hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1588 - Indatraline hydrochloride | C16H15Cl2N.HCl | CAS No. 96850-13-4
Description: Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
Alternative Names: Lu 19-005
Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

Compound Libraries

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Technical Data

M. Wt 328.67
Formula C16H15Cl2N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 96850-13-4
PubChem ID 10314472
InChI Key QICQDZXGZOVTEF-MELYUZJYSA-N
Smiles ClC(C=C3)=C(Cl)C=[C@@]3[C@H]2C1=CC=CC=C1[C@H](NC)C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.87 100
ethanol 16.43 50
water 3.29 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 328.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.21 mL 30.43 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868 PMID: 11123996

Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline and serotonin. J.Neurochem. 44 1615 PMID: 2580950

Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60 PMID: 10490887


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Citations for Indatraline hydrochloride

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