Indatraline hydrochloride

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Cat.No. 1588 - Indatraline hydrochloride | C16H15Cl2N.HCl | CAS No. 96850-13-4
Description: Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
Alternative Names: Lu 19-005
Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

Compound Libraries

Indatraline hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 328.67
Formula C16H15Cl2N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 96850-13-4
PubChem ID 10314472
Smiles ClC(C=C3)=C(Cl)C=[C@@]3[C@H]2C1=CC=CC=C1[C@H](NC)C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.87 100
ethanol 16.43 50
water 3.29 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 328.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.21 mL 30.43 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868 PMID: 11123996

Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline and serotonin. J.Neurochem. 44 1615 PMID: 2580950

Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60 PMID: 10490887

If you know of a relevant reference for Indatraline hydrochloride, please let us know.

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View all 5-HT Transporter Inhibitors

Keywords: Potent noradrenalin noradrenaline reuptake inhibitors inhibits 5-HT dopamine Noradrenalin Transporters NET Adrenergic Monoamine Neurotransmitter DAT Dopamine Serotonin SERT 5-Hydroxytryptamine Lu19-005 Lu 19-005 5-HT Transporters

Citations for Indatraline hydrochloride

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Literature in this Area


Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Indatraline hydrochloride


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