JHW 007 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4351 - JHW 007 hydrochloride | C24H29F2NO.HCl | CAS No. 202645-74-7
Description: High affinity dopamine uptake inhibitor
Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Compound Libraries

JHW 007 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 421.95
Formula C24H29F2NO.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 202645-74-7
PubChem ID 71771746
InChI Key RHYMGBAYGRUKNZ-DHWZJIOFSA-N
Smiles [H][C@@]12CC[C@@](C[C@H](OC(C4=CC=C(F)C=C4)C3=CC=C(F)C=C3)C2)([H])N1CCCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.19 100
ethanol 42.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kristensen et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharm.Rev. 63 585 PMID:

Kopajtic et al (2010) Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703 PMID: 20855444

Velaquez-Sanchez et al (2010) The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501 PMID: 20413276

Hiranita et al (014 ) Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats. J.Pharmacol.Exp.Ther. 348 174 PMID: 24194527


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View all Dopamine Transporter Inhibitors

Keywords: JHW007 dopamine uptake inhibitors inhibits DAT transporter Dopamine Transporters

1 Citation for JHW 007 hydrochloride

Citations are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:

Andersen et al (2015) Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. Stem Cell Reports 5 15650 PMID: 26503701


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Pathways for JHW 007 hydrochloride

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