JHW 007 hydrochloride

Pricing Availability   Qty
Cat.No. 4351 - JHW 007 hydrochloride | C24H29F2NO.HCl | CAS No. 202645-74-7
Description: High affinity dopamine uptake inhibitor
Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (4)

Biological Activity

Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Compound Libraries

JHW 007 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 421.95
Formula C24H29F2NO.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 202645-74-7
PubChem ID 71771746
Smiles [H][C@@]12CC[C@@](C[C@H](OC(C4=CC=C(F)C=C4)C3=CC=C(F)C=C3)C2)([H])N1CCCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.19 100
ethanol 42.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Kristensen et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharm.Rev. 63 585

Kopajtic et al (2010) DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703 PMID: 20855444

Velaquez-Sanchez et al (2010) The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501 PMID: 20413276

Hiranita et al (2014) Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats. J.Pharmacol.Exp.Ther. 348 174 PMID: 24194527

If you know of a relevant reference for JHW 007 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dopamine Transporter Inhibitors

Keywords: JHW 007 hydrochloride, JHW 007 hydrochloride supplier, JHW007, dopamine, uptake, inhibitors, inhibits, DAT, transporter, Dopamine, Transporters, 4351, Tocris Bioscience

1 Citation for JHW 007 hydrochloride

Citations are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:

Andersen et al (2015) Binding site residues control inhibitor selectivity in the human NE transporter but not in the human DA transporter. Stem Cell Reports 5 15650 PMID: 26503701

Do you know of a great paper that uses JHW 007 hydrochloride from Tocris? Please let us know.

Reviews for JHW 007 hydrochloride

There are currently no reviews for this product. Be the first to review JHW 007 hydrochloride and earn rewards!

Have you used JHW 007 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.