FFN 102 mesylate

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Cat.No. 5200 - FFN 102 mesylate | C11H11N2ClO3.CH3SO3H
Description: Selective fluorescent substrate of DAT and VMAT2
Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.

Licensing Information

Sold with the permission of Columbia University.

Technical Data

M. Wt 335.76
Formula C11H11N2ClO3.CH3SO3H
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
PubChem ID 91691121
InChI Key ZEZDFYRVIVZPAT-UHFFFAOYSA-N
Smiles ClC1=C(O)C=C(OC(C=C2CCN)=O)C2=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.58 100
water 6.72 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 335.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.89 mL 29.78 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References

References are publications that support the biological activity of the product.

Rodriguez et al (2013) Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proc.Natl.Acad.Sci.U.S.A. 110 870 PMID: 23277566

Sames et al (2013) Visualizing neurotransmitter secretion at individual synapses. ACS Chem.Neurosci. 4 648 PMID: 23862751

Lee et al (2010) Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 132 8828 PMID: 20540519


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