FFN 102 mesylate

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Description: Selective fluorescent substrate of DAT and VMAT2
Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for FFN 102 mesylate

FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.

Licensing Information

Sold with the permission of Columbia University.

Technical Data for FFN 102 mesylate

M. Wt 335.76
Formula C11H11N2ClO3.CH3SO3H
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1883548-92-2
PubChem ID 91691121
Smiles ClC1=C(O)C=C(OC(C=C2CCN)=O)C2=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FFN 102 mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 6.72 20 with gentle warming
DMSO 33.58 100

Preparing Stock Solutions for FFN 102 mesylate

The following data is based on the product molecular weight 335.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.89 mL 29.78 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for FFN 102 mesylate

References for FFN 102 mesylate

References are publications that support the biological activity of the product.

Rodriguez et al (2013) Fluorescent DA tracer resolves individual DArgic synapses and their activity in the brain. Proc.Natl.Acad.Sci.U.S.A. 110 870 PMID: 23277566

Sames et al (2013) Visualizing neurotransmitter secretion at individual synapses. ACS Chem.Neurosci. 4 648 PMID: 23862751

Lee et al (2010) Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 132 8828 PMID: 20540519

If you know of a relevant reference for FFN 102 mesylate, please let us know.

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Citations for FFN 102 mesylate

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