FFN 102 mesylate

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Cat.No. 5200 - FFN 102 mesylate | C11H11N2ClO3.CH3SO3H
Description: Selective fluorescent substrate of DAT and VMAT2
Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate
Purity: ≥99% (HPLC)

Biological Activity

pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake.

Licensing Information

Sold with the permission of Columbia University.

Technical Data

M. Wt 335.76
Formula C11H11N2ClO3.CH3SO3H
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
PubChem ID 91691121
Smiles ClC1=C(O)C=C(OC(C=C2CCN)=O)C2=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.58 100
water 6.72 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 335.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.89 mL 29.78 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Rodriguez et al (2013) Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proc.Natl.Acad.Sci.U.S.A. 110 870 PMID: 23277566

Sames et al (2013) Visualizing neurotransmitter secretion at individual synapses. ACS Chem.Neurosci. 4 648 PMID: 23862751

Lee et al (2010) Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 132 8828 PMID: 20540519

If you know of a relevant reference for FFN 102 mesylate, please let us know.

Keywords: FFN102 mesylate fluorescent probes neurotransmitters dopamine transporters DAT VMAT2 vesicular monoamine false inhibits inhibitors Fluorescent Probes

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
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  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for FFN 102 mesylate


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