Reserpine

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Cat.No. 2742 - Reserpine | C33H40N2O9 | CAS No. 50-55-5
Description: Inhibitor of vesicular monoamine transport
Chemical Name: (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.

Technical Data

M. Wt 608.68
Formula C33H40N2O9
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-55-5
PubChem ID 5770
InChI Key QEVHRUUCFGRFIF-MDEJGZGSSA-N
Smiles [H][C@@](N4CC3)(C[C@@]([C@H]([C@@](OC)=O)[C@@H](OC)[C@H](OC(C6=CC(OC)=C(OC)C(OC)=C6)=O)C5)([H])[C@@]5([H])C4)C2=C3C1=C(N2)C=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.09 10

Preparing Stock Solutions

The following data is based on the product molecular weight 608.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.21 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Schuldiner et al (1993) Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts. J.Biol.Chem. 268 29 PMID: 8416935

Heslop and Curzon (1999) Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology 38 883 PMID: 10465692

Metzger et al (2002) Inhibitory effect of reserpine on dopamine transporter function. Eur.J.Pharmacol. 456 39 PMID: 12450567


If you know of a relevant reference for Reserpine, please let us know.

View Related Products by Product Action

View all Vesicular Monoamine Transporter Inhibitors

Keywords: Reserpine, supplier, inhibitors, inhibits, vesicular, monoamine, transporters, Noradrenalin, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine, VMAT2, noradrenaline, Dopamine, Transporters, Vesicular, Monoamine, Transporters, Vesicular, Monoamine, Transporters, Tocris Bioscience

3 Citations for Reserpine

Citations are publications that use Tocris products. Selected citations for Reserpine include:

Prado et al (2012) Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. Cell Tissue Res 188 3062 PMID: 22379034

Berrios et al (2016) Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Neuropsychopharmacology 7 10702 PMID: 26869263

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. J Immunol 40 766 PMID: 25249058


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