Rimcazole dihydrochloride

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Cat.No. 1497 - Rimcazole dihydrochloride | C21H27N3.2HCl | CAS No. 75859-03-9
Description: σ2 antagonist. Also DAT inhibitor
Alternative Names: BW 234U
Chemical Name: 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Antagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

Technical Data

M. Wt 394.39
Formula C21H27N3.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 75859-03-9
PubChem ID 53388
InChI Key ZWHRZGHGYMUSRM-VWDRLOGHSA-N
Smiles C[C@H](N[C@H](C)C4)CN4CCCN1C3=C(C=CC=C3)C2=C1C=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.94 10

Preparing Stock Solutions

The following data is based on the product molecular weight 394.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.36 mL 126.78 mL 253.56 mL
0.5 mM 5.07 mL 25.36 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.36 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ferris et al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329 PMID: 2873494

Husbands et al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter. J.Med.Chem. 40 4340 PMID: 9435903

Matsumoto et al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology 41 878 PMID: 11684152


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View all σ2 Receptor Antagonists

Keywords: Rimcazole dihydrochloride, Rimcazole dihydrochloride supplier, σ2, sigma2, antagonists, DAT, reuptake, inhibitors, inhibits, Receptors, Dopamine, Transporters, Monoamine, Neurotransmitter, BW234U, BW, 234U, Sigma2, 1497, Tocris Bioscience

1 Citation for Rimcazole dihydrochloride

Citations are publications that use Tocris products. Selected citations for Rimcazole dihydrochloride include:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788


Do you know of a great paper that uses Rimcazole dihydrochloride from Tocris? Please let us know.

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Literature in this Area

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