Potent inhibitor of noradrenalin and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.82 mL||14.11 mL||28.22 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|10 mM||0.28 mL||1.41 mL||2.82 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the products' biological activity.
Tuomisto (1977) Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 42 101 PMID: 844493
Nakachi et al (1995) Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur.J.Pharmacol. 281 195 PMID: 7589207
Katz et al (2010) Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 24 1223 PMID: 19939862
If you know of a relevant reference for Nomifensine, please let us know.
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Keywords: Nomifensine, supplier, noradrenaline, noradrenalin, norepinephrine, NET, DAT, transporter, transports, dopamine, reuptake, uptake, inhibitors, inhibits, antidepressants, anti-depressants, Adrenergic, Transporters, Dopamine, Transporters, Dopamine, Transporters, Tocris Bioscience
1 Citation for Nomifensine
Citations are publications that use Tocris products. Selected citations for Nomifensine include:
Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842 PMID: 17923483
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