Pricing Availability   Qty
Description: Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
Chemical Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for Nomifensine

Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.

Technical Data for Nomifensine

M. Wt 354.4
Formula C16H18N2.C4H4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 32795-47-4
PubChem ID 5358907
Smiles NC1=CC=CC2=C1C[N+]([H])(C)CC2C3=CC=CC=C3.O=C(O)\C=C/C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nomifensine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.44 100

Preparing Stock Solutions for Nomifensine

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for Nomifensine

Certificate of Analysis / Product Datasheet
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References for Nomifensine

References are publications that support the biological activity of the product.

Tuomisto (1977) Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 42 101 PMID: 844493

Nakachi et al (1995) Effects of various DA uptake inhibitors on striatal extracellular DA levels and behaviours in rats. Eur.J.Pharmacol. 281 195 PMID: 7589207

Katz et al (2010) Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 24 1223 PMID: 19939862

If you know of a relevant reference for Nomifensine, please let us know.

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Keywords: Nomifensine, Nomifensine supplier, noradrenaline, noradrenalin, norepinephrine, NET, DAT, transporter, transports, dopamine, reuptake, uptake, inhibitors, inhibits, antidepressants, anti-depressants, depression, Adrenergic, Transporters, Dopamine, 1992, Tocris Bioscience

1 Citation for Nomifensine

Citations are publications that use Tocris products. Selected citations for Nomifensine include:

Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483

Do you know of a great paper that uses Nomifensine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.