Nomifensine

Pricing Availability Delivery Time Qty
Cat.No. 1992 - Nomifensine | C16H18N2.C4H4O4 | CAS No. 32795-47-4
Description: Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
Chemical Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent inhibitor of noradrenalin and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.

Technical Data

M. Wt 354.4
Formula C16H18N2.C4H4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 32795-47-4
PubChem ID 5358907
InChI Key GEOCVSMCLVIOEV-BTJKTKAUSA-N
Smiles NC1=CC=CC2=C1C[N+]([H])(C)CC2C3=CC=CC=C3.O=C(O)\C=C/C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tuomisto (1977) Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 42 101 PMID: 844493

Nakachi et al (1995) Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur.J.Pharmacol. 281 195 PMID: 7589207

Katz et al (2010) Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 24 1223 PMID: 19939862


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View all Dopamine Transporter Inhibitors

Keywords: noradrenaline noradrenalin norepinephrine NET DAT transporter transports dopamine reuptake uptake inhibitors inhibits antidepressants anti-depressants Dopamine Transporters

1 Citation for Nomifensine

Citations are publications that use Tocris products. Selected citations for Nomifensine include:

Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842 PMID: 17923483


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Pathways for Nomifensine

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