(S)-Duloxetine hydrochloride

Pricing Availability   Qty
Description: Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Literature (1)

Biological Activity for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Compound Libraries for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for (S)-Duloxetine hydrochloride

M. Wt 333.88
Formula C18H19NOS.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 136434-34-9
PubChem ID 60834
Smiles CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (S)-Duloxetine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 3.34 10 with gentle warming
DMSO 33.39 100

Preparing Stock Solutions for (S)-Duloxetine hydrochloride

The following data is based on the product molecular weight 333.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 14.98 mL 29.95 mL
5 mM 0.6 mL 3 mL 5.99 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for (S)-Duloxetine hydrochloride

References for (S)-Duloxetine hydrochloride

References are publications that support the biological activity of the product.

Wong et al (1988) LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049 PMID: 2850421

Kasamo et al (1996) Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278 PMID: 8613930

If you know of a relevant reference for (S)-Duloxetine hydrochloride, please let us know.

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4 Citations for (S)-Duloxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for (S)-Duloxetine hydrochloride include:

Skelly and Weiner (2014) Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav 4 468 PMID: 25161814

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

Gordon F et al (2019) Effect of monoamine reuptake inhibition and α1 blockade on respiratory arrest and death following electroshock-induced seizures in mice. Epilepsia 60 495-507 PMID: 30723893

Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022

Do you know of a great paper that uses (S)-Duloxetine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.