PD 168568 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3529 - PD 168568 dihydrochloride | C22H27N3O.2HCl | CAS No. 210688-56-5
Description: Potent and selective D4 antagonist
Chemical Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.

Compound Libraries

PD 168568 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 422.39
Formula C22H27N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 210688-56-5
PubChem ID 56972231
InChI Key RMNWLEGGYCVHFD-UHFFFAOYSA-N
Smiles CC1=C(C)C=CC(N2CCN(CCC(N4)C3=CC=CC=C3C4=O)CC2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.24 100
water 21.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 422.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.67 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Belliotti et al (1998) Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg.Med.Chem.Lett. 8 1499 PMID: 9873377


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Citations for PD 168568 dihydrochloride

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