A 412997 dihydrochloride

Pricing Availability   Qty
Description: Selective D4 agonist
Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for A 412997 dihydrochloride

A 412997 dihydrochloride is a selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Compound Libraries for A 412997 dihydrochloride

A 412997 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 412997 dihydrochloride

M. Wt 382.33
Formula C19H23N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1347744-96-0
PubChem ID 90488953
Smiles O=C(CN2CCC(C3=CC=CC=N3)CC2)NC1=CC=CC(C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 412997 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 38.23 100
DMSO 19.12 50

Preparing Stock Solutions for A 412997 dihydrochloride

The following data is based on the product molecular weight 382.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.16 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for A 412997 dihydrochloride

References for A 412997 dihydrochloride

References are publications that support the biological activity of the product.

Browman et al (2005) A-412997, a selective DA D4 agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 82 148 PMID: 16154186

Patel et al (2006) Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D4 agonist for the treatment of erectile dysfunction. J.Med.Chem. 49 7450 PMID: 17149874

Moreland et al (2005) A-412997 is a selective DA D4 receptor agonist in rats. Pharmacol.Biochem.Behav. 82 140 PMID: 16153699

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Citations for A 412997 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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Addiction Poster

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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.