A 412997 dihydrochloride

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Cat.No. 4552 - A 412997 dihydrochloride | C19H23N3O.2HCl | CAS No. 1347744-96-0
Description: Selective D4 agonist
Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Compound Libraries

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Technical Data

M. Wt 382.33
Formula C19H23N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1347744-96-0
PubChem ID 90488953
InChI Key KIGNSSHMCNBHQX-UHFFFAOYSA-N
Smiles O=C(CN2CCC(C3=CC=CC=N3)CC2)NC1=CC=CC(C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.12 50
ethanol 1.91 5
water 38.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.16 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Browman et al (2005) A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 82 148 PMID: 16154186

Patel et al (2006) Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J.Med.Chem. 49 7450 PMID: 17149874

Moreland et al (2005) A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol.Biochem.Behav. 82 140 PMID: 16153699


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