L-741,742 hydrochloride

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Cat.No. 1004 - L-741,742 hydrochloride | C23H25N2ClO.HCl | CAS No. 874882-93-6
Description: Highly selective D4 antagonist
Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 417.38
Formula C23H25N2ClO.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 874882-93-6
PubChem ID 133633
InChI Key LLBLNMUONVVVPG-UHFFFAOYSA-N
Smiles Cl.CC1=C(ON=C1C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.17 10

Preparing Stock Solutions

The following data is based on the product molecular weight 417.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.98 mL 23.96 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J. Med. Chem. 39 1943 PMID: 8642551

Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J.Med.Chem. 40 2374 PMID: 9240352


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1 Citation for L-741,742 hydrochloride

Citations are publications that use Tocris products. Selected citations for L-741,742 hydrochloride include:

Root et al (2015) Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci 35 3460 PMID: 25716845


Do you know of a great paper that uses L-741,742 hydrochloride from Tocris? If so please let us know.

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