WAY 100635 maleate

Pricing Availability Delivery Time Qty
Cat.No. 4380 - WAY 100635 maleate | C25H34N4O2.C4H4O4 | CAS No. 634908-75-1
Description: Potent, 5-HT1A silent antagonist. Also D4 agonist
Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.

Technical Data

M. Wt 538.64
Formula C25H34N4O2.C4H4O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 634908-75-1
PubChem ID 11957721
InChI Key XIGAHNVCEFUYOV-BTJKTKAUSA-N
Smiles O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.47 25

Preparing Stock Solutions

The following data is based on the product molecular weight 538.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.28 mL 18.57 mL
5 mM 0.37 mL 1.86 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mensonides-Harsema et al (2000) Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J.Med.Chem. 43 432 PMID: 10669570

Zhuang et al (1994) Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J.Med.Chem. 37 1406 PMID: 8182697

Forster et al (1995) A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur.J.Pharmacol. 281 81 PMID: 8566121

Chemel et al (2006) WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl). 188 244 PMID: 16915381


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Keywords: WAY100635 5-ht1a serotonin serotonergics selective antagonists dopamine D4 antagonists dopaminergics 5-HT1A Receptors

3 Citations for WAY 100635 maleate

Citations are publications that use Tocris products. Selected citations for WAY 100635 maleate include:

WieroĊ„ska et al (2015) The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Sci Transl Med 232 259 PMID: 25012236

Rawls et al (2010) 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144

Greene et al (2009) Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization. Neuropsychopharmacology 34 2459 PMID: 19553916


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