Desipramine hydrochloride

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Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (8)

Biological Activity for Desipramine hydrochloride

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data for Desipramine hydrochloride

M. Wt 302.84
Formula C18H22N2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58-28-6
PubChem ID 65327

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Desipramine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 30.28 100

Preparing Stock Solutions for Desipramine hydrochloride

The following data is based on the product molecular weight 302.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.02 mL
5 mM 0.66 mL 3.3 mL 6.6 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for Desipramine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Desipramine hydrochloride

References are publications that support the biological activity of the product.

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858

Zhao et al (2008) NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr. Neuropsychopharmacol. 33 3190

If you know of a relevant reference for Desipramine hydrochloride, please let us know.

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8 Citations for Desipramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

Tanaka et al (2018) A mesocortical DA circuit enables the cultural transmission of vocal behaviour. Nature 563 117 PMID: 30333629

Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886

LaRocca et al (2015) CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Neuropsychopharmacology 6 e1773 PMID: 26018734

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Proc Natl Acad Sci U S A 40 766 PMID: 25249058

Do you know of a great paper that uses Desipramine hydrochloride from Tocris? Please let us know.

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