Desipramine hydrochloride

Pricing Availability   Qty
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (8)
Literature (1)

Biological Activity for Desipramine hydrochloride

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data for Desipramine hydrochloride

M. Wt 302.84
Formula C18H22N2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58-28-6
PubChem ID 65327

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Desipramine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 30.28 100

Preparing Stock Solutions for Desipramine hydrochloride

The following data is based on the product molecular weight 302.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.02 mL
5 mM 0.66 mL 3.3 mL 6.6 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for Desipramine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Desipramine hydrochloride

References are publications that support the biological activity of the product.

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858

Zhao et al (2008) NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr. Neuropsychopharmacol. 33 3190

If you know of a relevant reference for Desipramine hydrochloride, please let us know.

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Keywords: Desipramine hydrochloride, Desipramine hydrochloride supplier, Selective, inhibitors, inhibits, noradrenaline, transporters, Transporter, NET, Adrenergic, Monoamine, Neurotransmitter, Transporters, 3067, Tocris Bioscience

8 Citations for Desipramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

Tanaka et al (2018) A mesocortical DA circuit enables the cultural transmission of vocal behaviour. Nature 563 117 PMID: 30333629

Choi et al (2013) Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by desipr. and cital. Korean J Physiol Pharmacol 17 321 PMID: 23946692

Kramer et al (2018) Combinatorial Expression of Grp and Neurod6 Defines DA Neuron Populations with Distinct Projection Patterns and Disease Vulnerability. Eneuro 5 PMID: 30135866

LaRocca et al (2015) CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Neuropsychopharmacology 6 e1773 PMID: 26018734

Do you know of a great paper that uses Desipramine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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