Desipramine hydrochloride

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Cat.No. 3067 - Desipramine hydrochloride | C18H22N2.HCl | CAS No. 58-28-6
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data

M. Wt 302.84
Formula C18H22N2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58-28-6
PubChem ID 65327
InChI Key XAEWZDYWZHIUCT-UHFFFAOYSA-N
Smiles CNCCCN2C1=CC=CC=C1CCC3=C2C=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.02 mL
5 mM 0.66 mL 3.3 mL 6.6 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858

Zhao et al (2008) Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacol. 33 3190


If you know of a relevant reference for Desipramine hydrochloride, please let us know.

View Related Products by Product Action

View all Adrenergic Transporter Inhibitors

Keywords: Desipramine hydrochloride, Desipramine hydrochloride supplier, Selective, inhibitors, inhibits, noradrenaline, transporters, Transporter, NET, Adrenergic, Monoamine, Neurotransmitter, Transporters, 3067, Tocris Bioscience

6 Citations for Desipramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

Choi et al (2013) Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram. Korean J Physiol Pharmacol 17 321 PMID: 23946692

Chou et al (2018) (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951

LaRocca et al (2015) CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Neuropsychopharmacology 6 e1773 PMID: 26018734

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Proc Natl Acad Sci U S A 40 766 PMID: 25249058


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Literature in this Area

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