Noradrenaline bitartrate
Biological Activity
Endogenous adrenergic hormone and neurotransmitter. A classical stress hormone; underlies the fight or flight response, along with adrenaline. Increases heart rate. Vasoconstrictor.
Technical Data
| M. Wt | 319.26 |
| Formula | C8H11NO3.C4H6O6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 108341-18-0 |
| PubChem ID | 25127519 |
| InChI Key | WNPNNLQNNJQYFA-YIDNRZKSSA-N |
| Smiles | O[C@@H](CN)C1=CC(O)=C(O)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.93 | 100 | |
| water | 31.93 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Bunney et al (1965) Norepinephrine in depressive reactions. A review. Arch.Gen.Psychiatry. 13 483 PMID: 5320621
Gary et al (1985) Stress and brain noradrenaline: A review. Neuroscience & Biobehavioral Reviews 9 233 PMID:
Lewitt et al (2012) Norepinephrine: the next therapeutics frontier for Parkinson's disease. Transl.Neurodegener. 1 4 PMID: 23211006
If you know of a relevant reference for Noradrenaline bitartrate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: endogenous adrenergic hormones neurotransmitters vasoconstrictor stress Norepinephrine Non-selective Adrenergic Alpha Receptors
2 Citations for Noradrenaline bitartrate
Citations are publications that use Tocris products. Selected citations for Noradrenaline bitartrate include:
Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196
Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Do you know of a great paper that uses Noradrenaline bitartrate from Tocris? If so please let us know.
Literature in this Area
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
