Noradrenaline bitartrate

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Description: Endogenous adrenergic hormone and neurotransmitter
Alternative Names: Norepinephrine
Chemical Name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (L-(+))-bitartrate salt
Purity: ≥99% (HPLC)
Citations (9)
Reviews (3)
Literature (1)

Biological Activity for Noradrenaline bitartrate

Noradrenaline bitartrate is an endogenous adrenergic hormone and neurotransmitter. A classical stress hormone; underlies the fight or flight response, along with adrenaline. Increases heart rate. Vasoconstrictor.

Technical Data for Noradrenaline bitartrate

M. Wt 319.26
Formula C8H11NO3.C4H6O6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 51-40-1
PubChem ID 25127519
Smiles O[C@@H](CN)C1=CC(O)=C(O)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Noradrenaline bitartrate

Solvent Max Conc. mg/mL Max Conc. mM
water 31.93 100
DMSO 31.93 100

Preparing Stock Solutions for Noradrenaline bitartrate

The following data is based on the product molecular weight 319.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for Noradrenaline bitartrate

Certificate of Analysis / Product Datasheet
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References for Noradrenaline bitartrate

References are publications that support the biological activity of the product.

Bunney et al (1965) NE in depressive reactions. A review. Arch.Gen.Psychiatry. 13 483 PMID: 5320621

Gary et al (1985) Stress and brain noradrenaline: A review. Neuroscience & Biobehavioral Reviews 9 233

Lewitt et al (2012) NE: the next therapeutics frontier for Parkinson's disease. Transl.Neurodegener. 1 4 PMID: 23211006

If you know of a relevant reference for Noradrenaline bitartrate, please let us know.

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Keywords: Noradrenaline bitartrate, Noradrenaline bitartrate supplier, endogenous, adrenergic, hormones, neurotransmitters, vasoconstrictor, stress, 108341-18-0, Norepinephrine, Non-selective, Adrenergic, Alpha, Receptors, Beta, Transporters, 5169, Tocris Bioscience

9 Citations for Noradrenaline bitartrate

Citations are publications that use Tocris products. Selected citations for Noradrenaline bitartrate include:

Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084

Khaled et al (2020) Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. Elife 9 PMID: 32234214

Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196

Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

Do you know of a great paper that uses Noradrenaline bitartrate from Tocris? Please let us know.

Reviews for Noradrenaline bitartrate

Average Rating: 4.7 (Based on 3 Reviews.)

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Noradrenaline is used in culture of HL-1 cells..
By Anonymous on 07/05/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1

HL-1 cells were cultured in Claycomb medium with 10% FBS, 1 % penicillin/ streptomycin, 0.1 mM noradrenaline and 2 mM L-glutamine.

review image

Noradrenaline elevates cardiomyocytes shortening.
By Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary ventricular cardiomyocytes

Primary mouse ventricular cardiomyocytes were treated with Noradrenaline bitartrate (NA, 5 µM) for 5 min and stimulated at 1 Hz frequency to follow cell shortening. NA increased cell shortening (shown in Image).

review image

By Anonymous on 10/02/2018
Assay Type: Ex Vivo
Species: Mouse

Elicits vasoconstriction within minutes. Used at 10 uM

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.