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Submit ReviewNoradrenaline bitartrate
Description: Endogenous adrenergic hormone and neurotransmitter
Alternative Names: Norepinephrine
Chemical Name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (L-(+))-bitartrate salt
Purity: ≥99% (HPLC)
Biological Activity for Noradrenaline bitartrate
Noradrenaline bitartrate is an endogenous adrenergic hormone and neurotransmitter. A classical stress hormone; underlies the fight or flight response, along with adrenaline. Increases heart rate. Vasoconstrictor.
Technical Data for Noradrenaline bitartrate
| M. Wt | 319.26 |
| Formula | C8H11NO3.C4H6O6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 51-40-1 |
| PubChem ID | 25127519 |
| InChI Key | WNPNNLQNNJQYFA-YIDNRZKSSA-N |
| Smiles | O[C@@H](CN)C1=CC(O)=C(O)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Noradrenaline bitartrate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.93 | 100 | |
| DMSO | 31.93 | 100 |
Preparing Stock Solutions for Noradrenaline bitartrate
The following data is based on the product molecular weight 319.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Noradrenaline bitartrate
References for Noradrenaline bitartrate
References are publications that support the biological activity of the product.
Bunney et al (1965) NE in depressive reactions. A review. Arch.Gen.Psychiatry. 13 483 PMID: 5320621
Gary et al (1985) Stress and brain noradrenaline: A review. Neuroscience & Biobehavioral Reviews 9 233
Lewitt et al (2012) NE: the next therapeutics frontier for Parkinson's disease. Transl.Neurodegener. 1 4 PMID: 23211006
If you know of a relevant reference for Noradrenaline bitartrate, please let us know.
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Keywords: Noradrenaline bitartrate, Noradrenaline bitartrate supplier, endogenous, adrenergic, hormones, neurotransmitters, vasoconstrictor, stress, 108341-18-0, Norepinephrine, Non-selective, Adrenergic, Alpha, Receptors, Beta, Transporters, 5169, Tocris Bioscience
9 Citations for Noradrenaline bitartrate
Citations are publications that use Tocris products. Selected citations for Noradrenaline bitartrate include:
Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Jordi et al (2022) Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice. J Neurochem 160 218-233 PMID: 34816436
Xinzhong et al (2022) Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain. Neuron 110 209-220.e6 PMID: 34752775
David E et al (2022) A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 185 3390-3407.e18 PMID: 36055200
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Khaled et al (2020) Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. Elife 9 PMID: 32234214
S et al (2023) Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats. Neurobiol Stress 24 100539 PMID: 37131490
Asya et al (2021) Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation. Immunity 54 1022-1036.e8 PMID: 33932356
Do you know of a great paper that uses Noradrenaline bitartrate from Tocris? Please let us know.
Reviews for Noradrenaline bitartrate
Average Rating: 4.7 (Based on 3 Reviews.)
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Noradrenaline is used in culture of HL-1 cells..
By
Anonymous on 07/05/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1
HL-1 cells were cultured in Claycomb medium with 10% FBS, 1 % penicillin/ streptomycin, 0.1 mM noradrenaline and 2 mM L-glutamine.
Noradrenaline elevates cardiomyocytes shortening.
By
Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary ventricular cardiomyocytes
Primary mouse ventricular cardiomyocytes were treated with Noradrenaline bitartrate (NA, 5 µM) for 5 min and stimulated at 1 Hz frequency to follow cell shortening. NA increased cell shortening (shown in Image).
Vasoconstrictor.
By
Anonymous on 10/02/2018
Assay Type: Ex Vivo
Species: Mouse
Elicits vasoconstriction within minutes. Used at 10 uM
Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.