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Submit ReviewNoradrenaline bitartrate
Description: Endogenous adrenergic hormone and neurotransmitter
Alternative Names: Norepinephrine
Chemical Name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (L-(+))-bitartrate salt
Purity: ≥99% (HPLC)
Biological Activity
Endogenous adrenergic hormone and neurotransmitter. A classical stress hormone; underlies the fight or flight response, along with adrenaline. Increases heart rate. Vasoconstrictor.
Technical Data
| M. Wt | 319.26 |
| Formula | C8H11NO3.C4H6O6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 108341-18-0 |
| PubChem ID | 25127519 |
| InChI Key | WNPNNLQNNJQYFA-YIDNRZKSSA-N |
| Smiles | O[C@@H](CN)C1=CC(O)=C(O)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.93 | 100 | |
| DMSO | 31.93 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Bunney et al (1965) NE in depressive reactions. A review. Arch.Gen.Psychiatry. 13 483 PMID: 5320621
Gary et al (1985) Stress and brain noradrenaline: A review. Neuroscience & Biobehavioral Reviews 9 233
Lewitt et al (2012) NE: the next therapeutics frontier for Parkinson's disease. Transl.Neurodegener. 1 4 PMID: 23211006
If you know of a relevant reference for Noradrenaline bitartrate, please let us know.
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Keywords: Noradrenaline bitartrate, Noradrenaline bitartrate supplier, endogenous, adrenergic, hormones, neurotransmitters, vasoconstrictor, stress, Norepinephrine, Non-selective, Adrenergic, Alpha, Receptors, Beta, Transporters, 5169, Tocris Bioscience
2 Citations for Noradrenaline bitartrate
Citations are publications that use Tocris products. Selected citations for Noradrenaline bitartrate include:
Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Do you know of a great paper that uses Noradrenaline bitartrate from Tocris? Please let us know.
Reviews for Noradrenaline bitartrate
Average Rating: 4.7 (Based on 3 Reviews.)
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Noradrenaline is used in culture of HL-1 cells..
By
Anonymous on 07/05/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1
HL-1 cells were cultured in Claycomb medium with 10% FBS, 1 % penicillin/ streptomycin, 0.1 mM noradrenaline and 2 mM L-glutamine.
Noradrenaline elevates cardiomyocytes shortening.
By
Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary ventricular cardiomyocytes
Primary mouse ventricular cardiomyocytes were treated with Noradrenaline bitartrate (NA, 5 µM) for 5 min and stimulated at 1 Hz frequency to follow cell shortening. NA increased cell shortening (shown in Image).
Vasoconstrictor.
By
Anonymous on 10/02/2018
Assay Type: Ex Vivo
Species: Mouse
Elicits vasoconstriction within minutes. Used at 10 uM
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