Tomoxetine hydrochloride

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Cat.No. 2011 - Tomoxetine hydrochloride | C17H21NO.HCl | CAS No. 82248-59-7
Description: Potent, selective noradrenalin re-uptake inhibitor
Alternative Names: Atomoxetine, LY 139603
Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (4)

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Deuterated analog also available.

Technical Data

M. Wt 291.82
Formula C17H21NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 82248-59-7
PubChem ID 54840
Smiles Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 14.59 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 291.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.13 mL 34.27 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Wong et al (1982) A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61 PMID: 6123593

Bymaster et al (2002) Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699 PMID: 12431845

If you know of a relevant reference for Tomoxetine hydrochloride, please let us know.

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4 Citations for Tomoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671 PMID: 24481568

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53 PMID: 25332454

Achterberg et al (2015) Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161 PMID: 25568111

Finnema et al (2015) Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Toxins (Basel) 18 PMID: 25522417

Do you know of a great paper that uses Tomoxetine hydrochloride from Tocris? If so please let us know.

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