Tomoxetine hydrochloride

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Cat.No. 2011 - Tomoxetine hydrochloride | C17H21NO.HCl | CAS No. 82248-59-7
Description: Potent and selective noradrenalin re-uptake inhibitor
Alternative Names: Atomoxetine, LY 139603
Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Deuterated analog also available.

Technical Data

M. Wt 291.82
Formula C17H21NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 82248-59-7
PubChem ID 54840
InChI Key LUCXVPAZUDVVBT-UNTBIKODSA-N
Smiles Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.59 50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 291.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.85 mL 34.27 mL 68.54 mL
2.5 mM 1.37 mL 6.85 mL 13.71 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
25 mM 0.14 mL 0.69 mL 1.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wong et al (1982) A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61 PMID: 6123593

Bymaster et al (2002) Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699 PMID: 12431845


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5 Citations for Tomoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671 PMID: 24481568

Kobayashi et al (2010) Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine. Neuropsychopharmacology 35 1560 PMID: 20393461

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53 PMID: 25332454

Achterberg et al (2015) Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161 PMID: 25568111


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Literature in this Area

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