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Biological Activity for Nisoxetine hydrochloride
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.
Technical Data for Nisoxetine hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nisoxetine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Nisoxetine hydrochloride
The following data is based on the product molecular weight 307.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.24 mL||32.49 mL|
|5 mM||0.65 mL||3.25 mL||6.5 mL|
|10 mM||0.32 mL||1.62 mL||3.25 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
Product Datasheets for Nisoxetine hydrochloride
References for Nisoxetine hydrochloride
References are publications that support the biological activity of the product.
Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63 PMID: 8684598
Shearman and Meyer (1998) NE transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736 PMID: 9454822
Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 17 755 PMID: 1207394
Zhu et al (1997) Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134 PMID: 8978719
If you know of a relevant reference for Nisoxetine hydrochloride, please let us know.
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Keywords: Nisoxetine hydrochloride, Nisoxetine hydrochloride supplier, Noradrenalin, reuptake, inhibitors, inhibits, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, noradrenaline, 1025, Tocris Bioscience
5 Citations for Nisoxetine hydrochloride
Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:
Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482
Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant. J Neurosci 115 1643 PMID: 20969573
Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748
Bassi et al (2019) Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis. Front Neurol 10 30 PMID: 30761069
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Front Cell Neurosci 29 15551 PMID: 20007479
Do you know of a great paper that uses Nisoxetine hydrochloride from Tocris? Please let us know.
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Literature in this Area
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