A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||30.78||100|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.24 mL||32.49 mL|
|5 mM||0.65 mL||3.25 mL||6.5 mL|
|10 mM||0.32 mL||1.62 mL||3.25 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63 PMID: 8684598
Shearman and Meyer (1998) Norepinephrine transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736 PMID: 9454822
Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart. Life Sci. 17 755 PMID: 1207394
Zhu et al (1997) Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134 PMID: 8978719
If you know of a relevant reference for Nisoxetine hydrochloride, please let us know.
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Keywords: Nisoxetine hydrochloride, supplier, Noradrenalin, reuptake, inhibitors, inhibits, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, noradrenaline, Adrenergic, Transporters, Tocris Bioscience
3 Citations for Nisoxetine hydrochloride
Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:
Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurosci 115 1643 PMID: 20969573
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Front Cell Neurosci 29 15551 PMID: 20007479
Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482
Do you know of a great paper that uses Nisoxetine hydrochloride from Tocris? If so please let us know.