Nisoxetine hydrochloride

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Cat.No. 1025 - Nisoxetine hydrochloride | C17H21NO2.HCl | CAS No. 57754-86-6
Description: Noradrenalin re-uptake inhibitor
Chemical Name: (±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data

M. Wt 307.82
Formula C17H21NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 57754-86-6
PubChem ID 134453
InChI Key LCEURBZEQJZUPV-UHFFFAOYSA-N
Smiles Cl.CNCCC(OC1=CC=CC=C1OC)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 307.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.24 mL 32.49 mL
5 mM 0.65 mL 3.25 mL 6.5 mL
10 mM 0.32 mL 1.62 mL 3.25 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63 PMID: 8684598

Shearman and Meyer (1998) NE transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736 PMID: 9454822

Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 17 755 PMID: 1207394

Zhu et al (1997) Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134 PMID: 8978719


If you know of a relevant reference for Nisoxetine hydrochloride, please let us know.

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5 Citations for Nisoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:

Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748

Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant. J Neurosci 115 1643 PMID: 20969573

Bassi et al (2019) Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis. Front Neurol 10 30 PMID: 30761069

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482


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Literature in this Area

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