Nisoxetine hydrochloride

Pricing Availability   Qty
Description: Noradrenalin re-uptake inhibitor
Chemical Name: (±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for Nisoxetine hydrochloride

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data for Nisoxetine hydrochloride

M. Wt 307.82
Formula C17H21NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 57754-86-6
PubChem ID 134453

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nisoxetine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 30.78 100

Preparing Stock Solutions for Nisoxetine hydrochloride

The following data is based on the product molecular weight 307.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.24 mL 32.49 mL
5 mM 0.65 mL 3.25 mL 6.5 mL
10 mM 0.32 mL 1.62 mL 3.25 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Nisoxetine hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Nisoxetine hydrochloride

References are publications that support the biological activity of the product.

Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63 PMID: 8684598

Shearman and Meyer (1998) NE transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736 PMID: 9454822

Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 17 755 PMID: 1207394

Zhu et al (1997) Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134 PMID: 8978719

If you know of a relevant reference for Nisoxetine hydrochloride, please let us know.

View Related Products by Product Action

View all Adrenergic Transporter Inhibitors

Keywords: Nisoxetine hydrochloride, Nisoxetine hydrochloride supplier, Noradrenalin, reuptake, inhibitors, inhibits, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, noradrenaline, 1025, Tocris Bioscience

5 Citations for Nisoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482

Bassi et al (2019) Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis. Front Neurol 10 30 PMID: 30761069

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Front Cell Neurosci 29 15551 PMID: 20007479

Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748

Do you know of a great paper that uses Nisoxetine hydrochloride from Tocris? Please let us know.

Reviews for Nisoxetine hydrochloride

There are currently no reviews for this product. Be the first to review Nisoxetine hydrochloride and earn rewards!

Have you used Nisoxetine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review