You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Venlafaxine hydrochloride
Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.
Compound Libraries for Venlafaxine hydrochloride
Technical Data for Venlafaxine hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Venlafaxine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Venlafaxine hydrochloride
The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.93 mL||31.86 mL|
|5 mM||0.64 mL||3.19 mL||6.37 mL|
|10 mM||0.32 mL||1.59 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
Product Datasheets for Venlafaxine hydrochloride
References for Venlafaxine hydrochloride
References are publications that support the biological activity of the product.
Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103 PMID: 16325805
Gould et al (2006) A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters. Biol.Psychiatry 59 408 PMID: 16140280
Bymaster et al (2001) Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871 PMID: 11750180
If you know of a relevant reference for Venlafaxine hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Venlafaxine hydrochloride, Venlafaxine hydrochloride supplier, Dual, serotonin/noradrenaline, reuptake, inhibitors, inhibits, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, SERT, 5-HT, 5-Hydroxytryptamine, Wy45030, Wy, 45030, 2917, Tocris Bioscience
3 Citations for Venlafaxine hydrochloride
Citations are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165 PMID: 25740288
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Do you know of a great paper that uses Venlafaxine hydrochloride from Tocris? Please let us know.
Reviews for Venlafaxine hydrochloride
There are currently no reviews for this product. Be the first to review Venlafaxine hydrochloride and earn rewards!
Have you used Venlafaxine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.