Venlafaxine hydrochloride

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Cat.No. 2917 - Venlafaxine hydrochloride | C17H27NO2.HCl | CAS No. 99300-78-4
Description: Dual serotonin/noradrenalin re-uptake inhibitor
Alternative Names: Wy 45030
Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Compound Libraries

Venlafaxine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 313.86
Formula C17H27NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99300-78-4
PubChem ID 62923
Smiles OC2(CCCCC2)C(CN(C)C)C1=CC=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 15.69 50
ethanol 31.39 100
water 31.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103 PMID: 16325805

Gould et al (2006) A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol.Psychiatry 59 408 PMID: 16140280

Bymaster et al (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871 PMID:

If you know of a relevant reference for Venlafaxine hydrochloride, please let us know.

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1 Citation for Venlafaxine hydrochloride

Citations are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165 PMID: 25740288

Do you know of a great paper that uses Venlafaxine hydrochloride from Tocris? If so please let us know.

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