Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.93 mL||31.86 mL|
|5 mM||0.64 mL||3.19 mL||6.37 mL|
|10 mM||0.32 mL||1.59 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103 PMID: 16325805
Gould et al (2006) A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol.Psychiatry 59 408 PMID: 16140280
Bymaster et al (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871 PMID:
If you know of a relevant reference for Venlafaxine hydrochloride, please let us know.
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Keywords: Dual serotonin/noradrenaline reuptake inhibitors inhibits NET Adrenergic Transporters Monoamine Neurotransmitter SERT 5-HT 5-Hydroxytryptamine Wy45030 Wy 45030 5-HT Transporters
1 Citation for Venlafaxine hydrochloride
Citations are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:
Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165 PMID: 25740288
Do you know of a great paper that uses Venlafaxine hydrochloride from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.