Venlafaxine hydrochloride

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Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Wy 45030
Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for Venlafaxine hydrochloride

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Compound Libraries for Venlafaxine hydrochloride

Venlafaxine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Venlafaxine hydrochloride

M. Wt 313.86
Formula C17H27NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99300-78-4
PubChem ID 62923
Smiles OC2(CCCCC2)C(CN(C)C)C1=CC=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Venlafaxine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 31.39 100
DMSO 15.69 50

Preparing Stock Solutions for Venlafaxine hydrochloride

The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for Venlafaxine hydrochloride

References for Venlafaxine hydrochloride

References are publications that support the biological activity of the product.

Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103 PMID: 16325805

Gould et al (2006) A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters. Biol.Psychiatry 59 408 PMID: 16140280

Bymaster et al (2001) Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871 PMID: 11750180

If you know of a relevant reference for Venlafaxine hydrochloride, please let us know.

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Keywords: Venlafaxine hydrochloride, Venlafaxine hydrochloride supplier, Dual, serotonin/noradrenaline, reuptake, inhibitors, inhibits, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, SERT, 5-HT, 5-Hydroxytryptamine, Wy45030, Wy, 45030, 2917, Tocris Bioscience

3 Citations for Venlafaxine hydrochloride

Citations are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126

Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165 PMID: 25740288

Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951

Do you know of a great paper that uses Venlafaxine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.