5-HT1B Receptors

Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0703 Anpirtoline hydrochloride
Highly potent 5-HT1B agonist. Also 5-HT3 antagonist
0638 CGS 12066B dimaleate
5-HT1B agonist
1032 CP 93129 dihydrochloride
5-HT1B agonist
1317 CP 94253 hydrochloride
Potent, selective 5-HT1B agonist
3665 Donitriptan hydrochloride
5-HT1B/1D agonist
3862 Eletriptan hydrobromide
Orally active, selective 5-HT1B/1D agonist
1860 Eltoprazine hydrochloride
5-HT1 receptor agonist/partial agonist
0901 5-Nonyloxytryptamine oxalate
Selective 5-HT1B agonist
5136 Rizatriptan benzoate
Potent 5-HT1B/1D agonist
3586 Sumatriptan succinate
5-HT1A/1B/1D receptor agonist
4657 Zolmitriptan
Potent 5-HT1B/1D/1F agonist

Antagonists

Cat No Product Name / Activity
0993 Cyanopindolol hemifumarate
5-HT1A/1B antagonist. Also β-adrenergic antagonist
1477 GR 127935 hydrochloride
Potent, selective 5-HT1B/1D antagonist
1054 GR 55562 dihydrochloride
5-HT1B antagonist
0992 Isamoltane hemifumarate
5-HT1B antagonist
3350 LY 393558
Dual 5-HT1B/1D antagonist and 5-HT re-uptake inhibitor
1413 NAS-181
Selective r5-HT1B antagonist. Active in vivo
0994 Pindolol
5-HT1A/1B antagonist. Also β-adrenergic antagonist
1060 (S)-(-)-Pindolol
5-HT1A/1B antagonist. Also β-adrenergic antagonist. More active enantiomer of pindolol (Cat. No. 0994)
1242 SB 216641 hydrochloride
Selective h5-HT1B antagonist
1221 SB 224289 hydrochloride
Selective 5-HT1B antagonist
1516 SDZ 21009
5-HT1A/1B antagonist. Also β-adrenoceptor antagonist

Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

External sources of pharmacological information for 5-HT1B Receptors :

Literature for 5-HT1B Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

5-HT1B Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1B NM_000863 P28222
Mouse Htr1b NM_010482 P28334
Rat Htr1b NM_022225 P28564