5-HT1B Receptors

Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
0703 Anpirtoline hydrochloride
Highly potent 5-HT1B agonist. Also 5-HT3 antagonist
0638 CGS 12066B dimaleate
5-HT1B agonist
1032 CP 93129 dihydrochloride
5-HT1B agonist
1317 CP 94253 hydrochloride
Potent, selective 5-HT1B agonist
3665 Donitriptan hydrochloride
5-HT1B/1D agonist
3862 Eletriptan hydrobromide
Orally active, selective 5-HT1B/1D agonist
1860 Eltoprazine hydrochloride
5-HT1 receptor agonist/partial agonist
0901 5-Nonyloxytryptamine oxalate
Selective 5-HT1B agonist
5136 Rizatriptan benzoate
Potent 5-HT1B/1D agonist
3586 Sumatriptan succinate
5-HT1A/1B/1D receptor agonist
4657 Zolmitriptan
Potent 5-HT1B/1D/1F agonist

Antagonists

Cat No Product Name / Activity
0993 Cyanopindolol hemifumarate
5-HT1A/1B antagonist. Also β-adrenergic antagonist
1477 GR 127935 hydrochloride
Potent, selective 5-HT1B/1D antagonist
1054 GR 55562 dihydrochloride
5-HT1B antagonist
0992 Isamoltane hemifumarate
5-HT1B antagonist
3350 LY 393558
Dual 5-HT1B/1D antagonist and 5-HT re-uptake inhibitor
1413 NAS-181
Selective r5-HT1B antagonist. Active in vivo
0994 Pindolol
5-HT1A/1B antagonist. Also β-adrenergic antagonist
1060 (S)-(-)-Pindolol
5-HT1A/1B antagonist. Also β-adrenergic antagonist. More active enantiomer of pindolol (Cat. No. 0994)
1242 SB 216641 hydrochloride
Selective h5-HT1B antagonist
1221 SB 224289 hydrochloride
Selective 5-HT1B antagonist
1516 SDZ 21009
5-HT1A/1B antagonist. Also β-adrenoceptor antagonist

Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

External sources of pharmacological information for 5-HT1B Receptors :

5-HT1B Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1B NM_000863 P28222
Mouse Htr1b NM_010482 P28334
Rat Htr1b NM_022225 P28564