5-ht1E Receptors

Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15); the receptor is closely related to the serotonin 5-HT1F receptor.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1129 BRL 54443
Potent 5-ht1E/F agonist

Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. The function of this receptor has yet to be elucidated, although its presence in certain areas of the brain suggests a role in the regulation of memory. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15); 5-ht1E is closely related to 5-HT1F though both are expressed differently in the brain.

External sources of pharmacological information for 5-ht1E Receptors :

Literature for 5-ht1E Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

5-ht1E Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1E NM_000865 P28566