Cyanopindolol hemifumarate

Pricing Availability   Qty
Cat.No. 0993 - Cyanopindolol hemifumarate | C16H21N3O2.½C4H4O4 | CAS No. 69906-86-1
Description: 5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.

Technical Data

M. Wt 345.4
Formula C16H21N3O2.½C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 69906-86-1
PubChem ID 45073413
InChI Key ZSBITJKBOWVCCI-WXXKFALUSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 345.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Engel et al (1986) Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 332 1 PMID: 2936965

Giles et al (1996) Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 117 1119 PMID: 8882605

Hoey et al (1996) Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 117 712 PMID: 8646418

Blue et al (1989) Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol. 96 246P


If you know of a relevant reference for Cyanopindolol hemifumarate, please let us know.

View Related Products by Product Action

View all 5-HT1A Receptor Antagonists

Keywords: Cyanopindolol hemifumarate, Cyanopindolol hemifumarate supplier, 5-HT1A/1B, antagonists, β-adrenergic, beta-adrenergic, β-adrenoceptor, beta-adrenoceptor, b-adrenergic, b-adrenoceptor, Serotonin, 5-HT1A, Receptors, 5-HT1B, Non-selective, Adrenergic, Beta, 0993, Tocris Bioscience

4 Citations for Cyanopindolol hemifumarate

Citations are publications that use Tocris products. Selected citations for Cyanopindolol hemifumarate include:

Brahmadevara et al (2004) ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol 142 781 PMID: 15205310

Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685

Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326


Do you know of a great paper that uses Cyanopindolol hemifumarate from Tocris? Please let us know.

Reviews for Cyanopindolol hemifumarate

There are currently no reviews for this product. Be the first to review Cyanopindolol hemifumarate and earn rewards!

Have you used Cyanopindolol hemifumarate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.