Cyanopindolol hemifumarate

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Cat.No. 0993 - Cyanopindolol hemifumarate | C16H21N3O2.½C4H4O4 | CAS No. 69906-86-1
Description: 5-HT1A/1B antagonist. Also β-adrenergic antagonist
Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.

Technical Data

M. Wt 345.4
Formula C16H21N3O2.½C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 69906-86-1
PubChem ID 45073413
InChI Key ZSBITJKBOWVCCI-WXXKFALUSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 345.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Engel et al (1986) Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 332 1 PMID: 2936965

Giles et al (1996) Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 117 1119 PMID: 8882605

Hoey et al (1996) Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 117 712 PMID: 8646418

Blue et al (1989) Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol. 96 246P PMID:


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Keywords: 5-HT1A/1B antagonists β-adrenergic beta-adrenergic β-adrenoceptor beta-adrenoceptor b-adrenergic b-adrenoceptor Serotonin 5-HT1A Receptors 5-HT1A Receptors

1 Citation for Cyanopindolol hemifumarate

Citations are publications that use Tocris products. Selected citations for Cyanopindolol hemifumarate include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685


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