CGS 12066B dimaleate

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Cat.No. 0638 - CGS 12066B dimaleate | C17H17F3N4.2C4H4O4 | CAS No. 109028-10-6
Description: 5-HT1B agonist
Chemical Name: 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.

Technical Data

M. Wt 566.49
Formula C17H17F3N4.2C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 109028-10-6
PubChem ID 9915956
InChI Key HTEVMLYDEWVIQE-SPIKMXEPSA-N
Smiles O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C1=CC3=C(N2C=CC=C2C(N4CCN(CC4)C)=N3)C=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.66 40
water 2.83 5

Preparing Stock Solutions

The following data is based on the product molecular weight 566.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.65 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Neale et al (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 136 1 PMID: 3496228

Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 339 675 PMID: 2770889

Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID: 10837852


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Keywords: CGS 12066B dimaleate, supplier, 5-HT1B, agonists, Serotonin, Receptors, 5-HT1, CGS12066B, dimaleate, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience

2 Citations for CGS 12066B dimaleate

Citations are publications that use Tocris products. Selected citations for CGS 12066B dimaleate include:

Khatri et al (2014) Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl) 231 1191 PMID: 23975037

Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120


Do you know of a great paper that uses CGS 12066B dimaleate from Tocris? If so please let us know.

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