GR 55562 dihydrochloride

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Cat.No. 1054 - GR 55562 dihydrochloride | C23H25N3O2.2HCl | CAS No. 159533-25-2
Description: 5-HT1B antagonist
Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (4)

Biological Activity

A selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 448.39
Formula C23H25N3O2.2HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 159533-25-2
PubChem ID 56972159
InChI Key KBKWJHYQFQONBJ-UHFFFAOYSA-N
Smiles Cl.Cl.CN(C)CCCC1=CC(=CC=C1O)C(=O)NC1=CC=C(C=C1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 448.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

MacLean et al (1996) Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery. Br.J.Pharmacol. 119 277 PMID: 8886409

Walsh et al (1995) The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors. Eur.J.Pharmacol. 287 79 PMID: 8666030

Connor et al (1995) Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia 15 99


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Keywords: GR 55562 dihydrochloride, GR 55562 dihydrochloride supplier, 5-HT1B, antagonists, Serotonin, Receptors, GR55562, dihydrochloride, GlaxoSmithKline, GSK, 1054, Tocris Bioscience

9 Citations for GR 55562 dihydrochloride

Citations are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

Johansson et al (2012) Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS One 7 e41852 PMID: 22848635

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863 PMID: 20228179

Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045

Zhou et al (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res 356 148 PMID: 29949735


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Reviews for GR 55562 dihydrochloride

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Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By Anonymous on 02/03/2020
Assay Type: In Vivo
Species: Mouse

100uM GR 55562

PMID: 28735749
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