GR 55562 dihydrochloride

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Description: 5-HT1B antagonist
Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (9)
Reviews (1)
Literature (2)

Biological Activity for GR 55562 dihydrochloride

GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for GR 55562 dihydrochloride

M. Wt 448.39
Formula C23H25N3O2.2HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 159533-25-2
PubChem ID 56972159
Smiles Cl.Cl.CN(C)CCCC1=CC(=CC=C1O)C(=O)NC1=CC=C(C=C1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GR 55562 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for GR 55562 dihydrochloride

The following data is based on the product molecular weight 448.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for GR 55562 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for GR 55562 dihydrochloride

References are publications that support the biological activity of the product.

MacLean et al (1996) Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery. Br.J.Pharmacol. 119 277 PMID: 8886409

Walsh et al (1995) The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors. Eur.J.Pharmacol. 287 79 PMID: 8666030

Connor et al (1995) Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia 15 99

If you know of a relevant reference for GR 55562 dihydrochloride, please let us know.

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Keywords: GR 55562 dihydrochloride, GR 55562 dihydrochloride supplier, 5-HT1B, antagonists, Serotonin, Receptors, GR55562, dihydrochloride, GlaxoSmithKline, GSK, 1054, Tocris Bioscience

9 Citations for GR 55562 dihydrochloride

Citations are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285

McDaid and Docherty (2001) Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. Br J Pharmacol 133 429 PMID: 11375260

Zhou et al (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res 356 148 PMID: 29949735

Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045

Do you know of a great paper that uses GR 55562 dihydrochloride from Tocris? Please let us know.

Reviews for GR 55562 dihydrochloride

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Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By Anonymous on 02/03/2020
Assay Type: In Vivo
Species: Mouse

100uM GR 55562

PMID: 28735749
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.