CP 93129 dihydrochloride

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Description: 5-HT1B agonist
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Datasheet
Citations (9)
Reviews (3)
Literature (2)

Biological Activity for CP 93129 dihydrochloride

CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 93129 dihydrochloride

M. Wt 288.18
Formula C12H13N3O.2HCl
Storage Desiccate at RT
CAS Number 879089-64-2
PubChem ID 46927988
InChI Key FLVJHUZZKVJQNH-UHFFFAOYSA-N
Smiles Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 93129 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.82 100
DMSO 28.82 100

Preparing Stock Solutions for CP 93129 dihydrochloride

The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.7 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.74 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets for CP 93129 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for CP 93129 dihydrochloride

References are publications that support the biological activity of the product.

Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241

Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287


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Keywords: CP 93129 dihydrochloride, CP 93129 dihydrochloride supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 1032, Tocris Bioscience

9 Citations for CP 93129 dihydrochloride

Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045

Medrihan et al (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron 95 564 PMID: 28735749

Zhou et al (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res 356 148 PMID: 29949735

Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552


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Reviews for CP 93129 dihydrochloride

Average Rating: 3.7 (Based on 3 Reviews.)

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3 Star
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Modulation of spontaneous interneuronal signalling.
By Sergiy Sylantyev on 12/10/2023
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Arcuate nucleus

CP 93129 was used to modulate spontaneous generation of action potentials in neurons of arcuate nucleus. Illustration: application of 100 nM CP 93129 (grey bar) decreases frequency of AP generation in living neuron.

PMID: 37827445
review image

5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

CP93129 (5-HT1B)10nM

PMID: 25692021
review image

Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By Anonymous on 02/03/2020
Assay Type: In Vivo
Species: Mouse

CP (10mM)

PMID: 28735749
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.