CP 93129 dihydrochloride

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Cat.No. 1032 - CP 93129 dihydrochloride | C12H13N3O.2HCl | CAS No. 879089-64-2
Description: 5-HT1B agonist
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Datasheet
Citations (9)
Reviews (2)
Literature (4)

Biological Activity

Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 288.18
Formula C12H13N3O.2HCl
Storage Desiccate at RT
CAS Number 879089-64-2
PubChem ID 46927988
InChI Key FLVJHUZZKVJQNH-UHFFFAOYSA-N
Smiles Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.82 100
water 28.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.7 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.74 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241

Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287


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Keywords: CP 93129 dihydrochloride, CP 93129 dihydrochloride supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 1032, Tocris Bioscience

9 Citations for CP 93129 dihydrochloride

Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517

Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045

Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239 PMID: 16846858

Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676 PMID: 16687477


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Reviews for CP 93129 dihydrochloride

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

CP93129 (5-HT1B)10nM

PMID: 25692021
review image

Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By Anonymous on 02/03/2020
Assay Type: In Vivo
Species: Mouse

CP (10mM)

PMID: 28735749
review image

Literature in this Area

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