CP 93129 dihydrochloride

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Cat.No. 1032 - CP 93129 dihydrochloride | C12H13N3O.2HCl | CAS No. 879089-64-2
Description: 5-HT1B agonist
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Datasheet
Citations (5)
Literature

Biological Activity

Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 288.18
Formula C12H13N3O.2HCl
Storage Desiccate at RT
CAS Number 879089-64-2
PubChem ID 46927988
InChI Key FLVJHUZZKVJQNH-UHFFFAOYSA-N
Smiles Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.7 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.74 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241 PMID:

Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 4381287


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Keywords: CP 93129 dihydrochloride, supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience

5 Citations for CP 93129 dihydrochloride

Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103 PMID: 25692021

Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915 PMID: 19056862

Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239 PMID: 16846858

Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676 PMID: 16687477


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Literature in this Area

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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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