CP 93129 dihydrochloride
Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.47 mL||17.35 mL||34.7 mL|
|5 mM||0.69 mL||3.47 mL||6.94 mL|
|10 mM||0.35 mL||1.74 mL||3.47 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the products' biological activity.
Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817
Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287
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Keywords: CP 93129 dihydrochloride, supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience
5 Citations for CP 93129 dihydrochloride
Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103 PMID: 25692021
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552
Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915 PMID: 19056862
Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239 PMID: 16846858
Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676 PMID: 16687477
Do you know of a great paper that uses CP 93129 dihydrochloride from Tocris? If so please let us know.
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