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Submit ReviewSumatriptan succinate
Description: 5-HT1A, 5-HT1B and 5-HT1D agonist
Alternative Names: GR 43175
Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Purity: ≥99% (HPLC)
Biological Activity for Sumatriptan succinate
Sumatriptan succinate is a 5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.
Compound Libraries for Sumatriptan succinate
Sumatriptan succinate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Sumatriptan succinate
| M. Wt | 413.49 |
| Formula | C14H21N3O2S.C4H6O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 103628-48-4 |
| PubChem ID | 59772 |
| InChI Key | PORMUFZNYQJOEI-UHFFFAOYSA-N |
| Smiles | O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sumatriptan succinate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.35 | 100 | |
| DMSO | 31.01 | 75 |
Preparing Stock Solutions for Sumatriptan succinate
The following data is based on the product molecular weight 413.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.09 mL | 24.18 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for Sumatriptan succinate
References for Sumatriptan succinate
References are publications that support the biological activity of the product.
Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133 PMID: 2545459
Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554 PMID: 2177047
Ottani et al (2004) Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 497 181 PMID: 15306203
If you know of a relevant reference for Sumatriptan succinate, please let us know.
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Keywords: Sumatriptan succinate, Sumatriptan succinate supplier, 5-HT1A/1B/1D, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, GR, 43175, Non-selective, 5-HT1, 5-HT1B, 5-HT1D, 3586, Tocris Bioscience
4 Citations for Sumatriptan succinate
Citations are publications that use Tocris products. Selected citations for Sumatriptan succinate include:
Leon F et al (2019) Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide. J Pharmacol Exp Ther 369 26-36 PMID: 30643015
Matsui & Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
Veronica A et al (2022) Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep 39 110795 PMID: 35545050
Do you know of a great paper that uses Sumatriptan succinate from Tocris? Please let us know.
Reviews for Sumatriptan succinate
Average Rating: 4 (Based on 1 Review.)
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
Assay Type: In Vivo
Species: Mouse
sumatriptan (1 μΜ)
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.