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Sumatriptan succinate

Cat. No. 3586 2 Citations 1 Review Submit a Review Datasheet / COA / SDS
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Cat.No. 3586 - Sumatriptan succinate | C14H21N3O2S.C4H6O4 | CAS No. 103628-48-4
Description: 5-HT1A, 5-HT1B and 5-HT1D agonist
Alternative Names: GR 43175
Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.

Compound Libraries

Sumatriptan succinate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 413.49
Formula C14H21N3O2S.C4H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103628-48-4
PubChem ID 59772
InChI Key PORMUFZNYQJOEI-UHFFFAOYSA-N
Smiles O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.35 100
DMSO 31.01 75

Preparing Stock Solutions

The following data is based on the product molecular weight 413.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133 PMID: 2545459

Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554 PMID: 2177047

Ottani et al (2004) Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol. 497 181 PMID: 15306203

If you know of a relevant reference for Sumatriptan succinate, please let us know.

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Keywords: Sumatriptan succinate, Sumatriptan succinate supplier, 5-HT1A/1B/1D, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, GR, 43175, Non-selective, 5-HT1, 5-HT1B, 5-HT1D, 3586, Tocris Bioscience

2 Citations for Sumatriptan succinate

Citations are publications that use Tocris products. Selected citations for Sumatriptan succinate include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

Matsui & Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

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Reviews for Sumatriptan succinate

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Inhibition of Synaptic Transmission in the VP.
By Anonymous on 02/02/2020
Assay Type: In Vivo
Species: Mouse

sumatriptan (1 μΜ)

PMID: 29949769
review image

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