Sumatriptan succinate
Biological Activity
5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.
Compound Libraries
Sumatriptan succinate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 413.49 |
| Formula | C14H21N3O2S.C4H6O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 103628-48-4 |
| PubChem ID | 59772 |
| InChI Key | PORMUFZNYQJOEI-UHFFFAOYSA-N |
| Smiles | O=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.35 | 100 | |
| DMSO | 31.01 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 413.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.09 mL | 24.18 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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References
References are publications that support the biological activity of the product.
Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133 PMID: 2545459
Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554 PMID: 2177047
Ottani et al (2004) Effect of sumatriptan in different models of pain in rats. Eur.J.Pharmacol. 497 181 PMID: 15306203
If you know of a relevant reference for Sumatriptan succinate, please let us know.
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Keywords: Sumatriptan succinate, Sumatriptan succinate supplier, 5-HT1A/1B/1D, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, GR, 43175, 5-HT1A, 5-HT1B, 5-HT1D, 3586, Tocris Bioscience
Citations for Sumatriptan succinate
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
