5-HT1F Receptors

Serotonin 5-HT1F receptors, previously known as 5-HT1Eβ receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3079 LY 334370 hydrochloride
Selective 5-HT1F agonist
2451 LY 344864 hydrochloride
Potent, selective 5-HT1F agonist
4657 Zolmitriptan
Potent 5-HT1B/1D/1F agonist

Serotonin 5-HT1F receptors, previously known as 5-HT1Eβ receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11).The physiological role of 5-HT1F receptors is currently unknown.

External sources of pharmacological information for 5-HT1F Receptors :

Literature for 5-HT1F Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

5-HT1F Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1F NM_000866 P30939
Mouse Htr1f NM_008310 Q02284
Rat Htr1f NM_021857 P30940