CP 94253 hydrochloride

Pricing Availability   Qty
Description: Potent and selective 5-HT1B agonist
Chemical Name: 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Purity: ≥98% (HPLC)
Citations (7)
Reviews (1)
Literature (2)

Biological Activity for CP 94253 hydrochloride

CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.

Compound Libraries for CP 94253 hydrochloride

CP 94253 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 94253 hydrochloride

M. Wt 293.8
Formula C15H19N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 845861-39-4
PubChem ID 11652258
Smiles Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 94253 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 7.34 25
DMSO 29.38 100

Preparing Stock Solutions for CP 94253 hydrochloride

The following data is based on the product molecular weight 293.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 17.02 mL 34.04 mL
5 mM 0.68 mL 3.4 mL 6.81 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets for CP 94253 hydrochloride

Certificate of Analysis / Product Datasheet
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References for CP 94253 hydrochloride

References are publications that support the biological activity of the product.

Fish et al (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146 391 PMID: 10550489

Knobelman et al (2000) Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors. J.Pharmacol.Exp.Ther. 292 1111 PMID: 10688630

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241

If you know of a relevant reference for CP 94253 hydrochloride, please let us know.

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7 Citations for CP 94253 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 94253 hydrochloride include:

Mansari et al (2015) Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Neuron 232 2343 PMID: 25665528

Doslikova et al (2013) 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci 33 9800 PMID: 23739976

Hagan et al (2012) 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse 66 1024 PMID: 22961814

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

Do you know of a great paper that uses CP 94253 hydrochloride from Tocris? Please let us know.

Reviews for CP 94253 hydrochloride

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CP-94253 reduces food intake in obese mice.
By Sergiy Sylantyev on 12/10/2023
Assay Type: In Vivo
Species: Mouse

CP-94253 was used to test an impact of 5HT-1B receptor on feeding behaviour in mice. Illustration: CP-94253 (16 mg/kg i.p.) significantly decreased high fat diet intake in obese mice compared to saline treatment. Repeated measures ANOVA followed by Dunnett’s post hoc tests, * - P<0.05, ** - P<0.01.

PMID: 37827445
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.