CP 94253 hydrochloride

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Cat.No. 1317 - CP 94253 hydrochloride | C15H19N3O.HCl | CAS No. 845861-39-4
Description: Potent, selective 5-HT1B agonist
Chemical Name: 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.

Compound Libraries

CP 94253 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 293.8
Formula C15H19N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 845861-39-4
PubChem ID 11652258
InChI Key PIIOXKQIZCVXMD-UHFFFAOYSA-N
Smiles Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.38 100
ethanol 7.34 25
water 7.34 25

Preparing Stock Solutions

The following data is based on the product molecular weight 293.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 17.02 mL 34.04 mL
5 mM 0.68 mL 3.4 mL 6.81 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fish et al (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146 391 PMID: 10550489

Knobelman et al (2000) Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors. J.Pharmacol.Exp.Ther. 292 1111 PMID: 10688630

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241 PMID:


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Keywords: CP 94253 hydrochloride, supplier, Potent, selective, 5-HT1B, agonists, Serotonin, Receptors, CP94253, hydrochloride, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience

5 Citations for CP 94253 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 94253 hydrochloride include:

Doslikova et al (2013) 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci 33 9800 PMID: 23739976

Eriksson et al (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Psychopharmacology (Berl) 18 1096 PMID: 23032875

McDevitt et al (2011) Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior. Pain 69 780 PMID: 21353664

Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Biol Psychiatry 51 239 PMID: 16846858

Mansari et al (2015) Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Neuron 232 2343 PMID: 25665528


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