Zolmitriptan

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Cat.No. 4657 - Zolmitriptan | C16H21N3O2 | CAS No. 139264-17-8
Description: Potent 5-HT1B/1D/1F agonist
Chemical Name: (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Potent 5-HT1B/1D/1F agonist (Ki values are 0.63, 5.01 and 63.09 nM for h5-HT1D, h5-HT1B and h5-HT1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.

Compound Libraries

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Technical Data

M. Wt 287.36
Formula C16H21N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 139264-17-8
PubChem ID 60857
InChI Key ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Smiles CN(C)CCC2=CNC1=CC=C(C[C@H](N3)COC3=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.74 100
ethanol 28.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 287.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References

References are publications that support the biological activity of the product.

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J.Neurophysiol. 106 925 PMID: 21653728

Pauwels et al (1997) How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines. Neuropharmacology 36 499 PMID: 9225275

Martin et al (1997) Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br.J.Pharmacol. 121 157 PMID: 9154322


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Keywords: Zolmitriptan, Zolmitriptan supplier, 5ht, 5-ht, serotonergics, 5ht1B, 5ht1D, 5ht1F, potent, agonists, excitatory, postsynaptic, potentials, migraine, neurogenic, plasma, protein, extravasation, 5-HT1B, Receptors, 5-HT1D, 5-HT1F, 4657, Tocris Bioscience

Citations for Zolmitriptan

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