Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.
Agonists |
Cat. No. | Product Name / Activity |
---|---|
0864 | GR 46611 |
5-HT1D agonist | |
0781 | L-694,247 |
5-HT1D agonist | |
2640 | L-703,664 succinate |
Selective 5-HT1D agonist | |
1985 | PNU 142633 |
Highly selective 5-HT1D agonist | |
5136 | Rizatriptan benzoate |
Potent 5-HT1B and 5-HT1D agonist | |
3586 | Sumatriptan succinate |
5-HT1A, 5-HT1B and 5-HT1D agonist | |
4657 | Zolmitriptan |
Potent 5-HT1B/1D/1F agonist | |
Antagonists |
Cat. No. | Product Name / Activity |
1207 | BRL 15572 hydrochloride |
Selective h5-HT1D antagonist | |
1477 | GR 127935 hydrochloride |
Potent and selective 5-HT1B and 5-HT1D antagonist | |
3078 | LY 310762 hydrochloride |
Selective 5-HT1D antagonist | |
3350 | LY 393558 |
Dual 5-HT1B and 5-HT1D antagonist; also 5-HT re-uptake inhibitor |
Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.
Tocris offers the following scientific literature for 5-HT1D Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.