5-HT1D Receptors
Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 3783 | CP 135807 |
| Selective 5-HT1D agonist | |
| 3665 | Donitriptan hydrochloride |
| 5-HT1B/1D agonist | |
| 3862 | Eletriptan hydrobromide |
| Orally active, selective 5-HT1B/1D agonist | |
| 0864 | GR 46611 |
| 5-HT1D agonist | |
| 0781 | L-694,247 |
| 5-HT1D agonist | |
| 2640 | L-703,664 succinate |
| Selective 5-HT1D receptor agonist | |
| 2556 | PNU 109291 |
| Potent and selective 5-HT1D agonist | |
| 1985 | PNU 142633 |
| Highly selective 5-HT1D agonist | |
| 5136 | Rizatriptan benzoate |
| Potent 5-HT1B/1D agonist | |
| 3586 | Sumatriptan succinate |
| 5-HT1A/1B/1D receptor agonist | |
| 4657 | Zolmitriptan |
| Potent 5-HT1B/1D/1F agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 1207 | BRL 15572 hydrochloride |
| Selective h5-HT1D antagonist | |
| 1477 | GR 127935 hydrochloride |
| Potent, selective 5-HT1B/1D antagonist | |
| 3078 | LY 310762 hydrochloride |
| 5-HT1D-preferring antagonist | |
| 3350 | LY 393558 |
| Dual 5-HT1B/1D antagonist and 5-HT re-uptake inhibitor | |
Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.
External sources of pharmacological information for 5-HT1D Receptors :
Literature for 5-HT1D Receptors
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Written by N. Barnes & J. Neumaler
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
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