5-HT1D Receptors

Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3783 CP 135807
Selective 5-HT1D agonist
3665 Donitriptan hydrochloride
5-HT1B/1D agonist
3862 Eletriptan hydrobromide
Orally active, selective 5-HT1B/1D agonist
0864 GR 46611
5-HT1D agonist
0781 L-694,247
5-HT1D agonist
2640 L-703,664 succinate
Selective 5-HT1D receptor agonist
2556 PNU 109291
Potent and selective 5-HT1D agonist
1985 PNU 142633
Highly selective 5-HT1D agonist
5136 Rizatriptan benzoate
Potent 5-HT1B/1D agonist
3586 Sumatriptan succinate
5-HT1A/1B/1D receptor agonist
4657 Zolmitriptan
Potent 5-HT1B/1D/1F agonist

Antagonists

Cat No Product Name / Activity
1207 BRL 15572 hydrochloride
Selective h5-HT1D antagonist
1477 GR 127935 hydrochloride
Potent, selective 5-HT1B/1D antagonist
3078 LY 310762 hydrochloride
5-HT1D-preferring antagonist
3350 LY 393558
Dual 5-HT1B/1D antagonist and 5-HT re-uptake inhibitor

Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.

External sources of pharmacological information for 5-HT1D Receptors :

Literature for 5-HT1D Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

5-HT1D Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1D NM_000864 P28221
Mouse Htr1d NM_008309 Q61224
Rat Htr1d NM_012852 P28565