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Biological Activity for NSC 74859
NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.
Compound Libraries for NSC 74859
Technical Data for NSC 74859
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 74859
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NSC 74859
The following data is based on the product molecular weight 365.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.69 mL||27.37 mL|
|5 mM||0.55 mL||2.74 mL||5.47 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References for NSC 74859
References are publications that support the biological activity of the product.
Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961 PMID: 19137011
Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391 PMID: 17463090
If you know of a relevant reference for NSC 74859, please let us know.
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Keywords: NSC 74859, NSC 74859 supplier, NSC74859, STAT3, inhibitors, inhibits, DNA-binding, apoptosis, S3I-201, STAT, 4655, Tocris Bioscience
2 Citations for NSC 74859
Citations are publications that use Tocris products. Selected citations for NSC 74859 include:
Edmund C et al (2020) Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer. Front Oncol 10 587132 PMID: 33330068
Yuan-Soon et al (2019) The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration. Cancers (Basel) 11 PMID: 31835799
Do you know of a great paper that uses NSC 74859 from Tocris? Please let us know.
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Literature in this Area
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