NSC 74859

Pricing Availability Delivery Time Qty
Cat.No. 4655 - NSC 74859 | C16H15NO7S | CAS No. 501919-59-1
Description: Selective STAT3 inhibitor
Alternative Names: S3I-201
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

Compound Libraries

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Technical Data

M. Wt 365.36
Formula C16H15NO7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 501919-59-1
PubChem ID 252682
InChI Key HWNUSGNZBAISFM-UHFFFAOYSA-N
Smiles CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 365.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961 PMID: 19137011

Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391 PMID: 17463090


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Keywords: NSC 74859, NSC 74859 supplier, NSC74859, STAT3, inhibitors, inhibits, DNA-binding, apoptosis, S3I-201, STAT, 4655, Tocris Bioscience

Citations for NSC 74859

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Literature in this Area

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Cancer

Cancer Research Product Guide

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Pathways for NSC 74859

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.