JAK-STAT Signaling Pathway
Ras Raf MEK ERK1/2 ERK1/2 Cytokines RTK EGFR JAK JAK JAK mTOR Akt STAT STAT STAT STAT STAT STAT Myc Bcl-XL PI3K Src Apoptosis Proteasome Cytokine
Receptor
Receptor
The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. In addition to their action on STATs, JAKs activate additional signaling molecules which leads to crossover with other pathways such as MAPK and Akt.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Kinase
Enzyme-linked Receptor
Transcription Factor
Other Protein
Prosurvival
