You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Pyrimethamine
Pyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.
Compound Libraries for Pyrimethamine
Technical Data for Pyrimethamine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pyrimethamine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pyrimethamine
The following data is based on the product molecular weight 248.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.02 mL||20.1 mL||40.21 mL|
|5 mM||0.8 mL||4.02 mL||8.04 mL|
|10 mM||0.4 mL||2.01 mL||4.02 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References for Pyrimethamine
References are publications that support the biological activity of the product.
Ito et al (2010) Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth. J.Pharmacol.Exp.Ther. 333 341 PMID: 20065018
Zimmerman et al (1987) Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth. Am.J.Clin.Nutr. 46 518 PMID: 3630970
Takakura et al (2011) Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 20 4143 PMID: 21821671
If you know of a relevant reference for Pyrimethamine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Pyrimethamine, Pyrimethamine supplier, inhibitors, inhibits, multidrug, and, toxin, extrusion, MATE, transporters, dihydrofolate, reductase, DHFR, STAT3, signal, transducer, activator, of, transcription, 3, Multidrug, Transporters, Dihydrofolate, Reductase, STAT, 3918, Tocris Bioscience
1 Citation for Pyrimethamine
Citations are publications that use Tocris products. Selected citations for Pyrimethamine include:
Hui et al (2020) Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chem Biol 27 622-634.e6 PMID: 32330442
Do you know of a great paper that uses Pyrimethamine from Tocris? Please let us know.
Reviews for Pyrimethamine
There are currently no reviews for this product. Be the first to review Pyrimethamine and earn rewards!
Have you used Pyrimethamine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.