Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.74 mL||23.68 mL||47.35 mL|
|5 mM||0.95 mL||4.74 mL||9.47 mL|
|10 mM||0.47 mL||2.37 mL||4.74 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005
If you know of a relevant reference for Stattic, please let us know.
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Keywords: Stattic, supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, STAT, Tocris Bioscience
10 Citations for Stattic
Citations are publications that use Tocris products. Selected citations for Stattic include:
Beales and Ogunwobi (2009) Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 42 305 PMID: 19153190
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. PLoS One 93 461 PMID: 25582338
Natarajan et al (2014) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. Cancer Res 9 e100405 PMID: 24945434
Shravah et al (2014) Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. Nat Commun 3 e29554 PMID: 25105067
Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126
Haynes et al (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4 2312 PMID: 23942241
Price et al (2013) Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. JAKSTAT 73 3441 PMID: 23729642
Hodge et al (2012) IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood 120 3774 PMID: 22976953
Katz et al (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3 608 PMID: 22689141
Do you know of a great paper that uses Stattic from Tocris? If so please let us know.