Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||9.47 mL||47.35 mL||94.7 mL|
|2.5 mM||1.89 mL||9.47 mL||18.94 mL|
|5 mM||0.95 mL||4.74 mL||9.47 mL|
|25 mM||0.19 mL||0.95 mL||1.89 mL|
References are publications that support the biological activity of the product.
Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005
If you know of a relevant reference for Stattic, please let us know.
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Keywords: Stattic, Stattic supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, 2798, Tocris Bioscience
15 Citations for Stattic
Citations are publications that use Tocris products. Selected citations for Stattic include:
Dong et al (2017) Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget 8 109161 PMID: 29312598
Natarajan et al (2014) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. Cancer Res 9 e100405 PMID: 24945434
Shravah et al (2014) Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. Nat Commun 3 e29554 PMID: 25105067
Price et al (2013) Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. JAKSTAT 73 3441 PMID: 23729642
Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. PLoS One 93 461 PMID: 25582338
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Conner et al (2014) Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci 34 14403 PMID: 25339752
Ko et al (2016) STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J 57 761 PMID: 26996579
Peda et al (2016) Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech 9 1051 PMID: 27491076
Liu et al (2013) Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS One 8 e75804 PMID: 24098399
Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126
Haynes et al (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4 2312 PMID: 23942241
Katz et al (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3 608 PMID: 22689141
Hodge et al (2012) IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood 120 3774 PMID: 22976953
Beales and Ogunwobi (2009) Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 42 305 PMID: 19153190
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Reviews for Stattic
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Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.
Literature in this Area
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