Stattic

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Cat.No. 2798 - Stattic | C8H5NO4S | CAS No. 19983-44-9
Description: Selective STAT3 inhibitor
Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Purity: ≥99% (HPLC)
Datasheet
Citations (15)
Reviews (1)
Literature
Pathways

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M. Wt 211.19
Formula C8H5NO4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 19983-44-9
PubChem ID 2779853
InChI Key ZRRGOUHITGRLBA-UHFFFAOYSA-N
Smiles O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.56 50
ethanol 1.06 5

Preparing Stock Solutions

The following data is based on the product molecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.47 mL 47.35 mL 94.7 mL
2.5 mM 1.89 mL 9.47 mL 18.94 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
25 mM 0.19 mL 0.95 mL 1.89 mL

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Product Datasheets

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References

References are publications that support the biological activity of the product.

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005


If you know of a relevant reference for Stattic, please let us know.

View Related Products by Product Action

View all STAT Inhibitors

Keywords: Stattic, Stattic supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, 2798, Tocris Bioscience

15 Citations for Stattic

Citations are publications that use Tocris products. Selected citations for Stattic include:

Dong et al (2017) Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget 8 109161 PMID: 29312598

Natarajan et al (2014) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. Cancer Res 9 e100405 PMID: 24945434

Shravah et al (2014) Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. Nat Commun 3 e29554 PMID: 25105067

Price et al (2013) Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. JAKSTAT 73 3441 PMID: 23729642

Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. PLoS One 93 461 PMID: 25582338

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Conner et al (2014) Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci 34 14403 PMID: 25339752

Ko et al (2016) STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J 57 761 PMID: 26996579

Peda et al (2016) Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech 9 1051 PMID: 27491076

Liu et al (2013) Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS One 8 e75804 PMID: 24098399

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Haynes et al (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4 2312 PMID: 23942241

Katz et al (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3 608 PMID: 22689141

Hodge et al (2012) IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood 120 3774 PMID: 22976953

Beales and Ogunwobi (2009) Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 42 305 PMID: 19153190


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Reviews for Stattic

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Static inhibition of STAT3 pathway
By Mark Stauffer on 01/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: U87

Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Stattic

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.