HJC 0416 hydrochloride

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Description: STAT3 inhibitor
Chemical Name: 2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)benzamide hydrochloride
Purity: ≥97% (HPLC)
Pathways (1)

Biological Activity for HJC 0416 hydrochloride

HJC 0416 hydrochloride is a STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.

Compound Libraries for HJC 0416 hydrochloride

HJC 0416 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for HJC 0416 hydrochloride

M. Wt 429.32
Formula C18H17ClN2O4S.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2415263-08-8
Smiles ClC(C=C1)=CC(C(NC2=CC=C3C=CS(=O)(C3=C2)=O)=O)=C1OCCCN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HJC 0416 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.93 100
water 8.59 20

Preparing Stock Solutions for HJC 0416 hydrochloride

The following data is based on the product molecular weight 429.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.65 mL 23.29 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets for HJC 0416 hydrochloride

References for HJC 0416 hydrochloride

References are publications that support the biological activity of the product.

Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID: 24904966

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Citations for HJC 0416 hydrochloride

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Pathways for HJC 0416 hydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.