VHL Targeting Ligands Plus Linkers

Products
Literature
Cat. No. Product Name / Activity
6463 VH 032 - linker 1
VH 032-PEG3-amine
6880 VH 032 - linker 10
VH 032-alkylC10-amine
6890 VH 032 - linker 11
VH 032-AlkylC8-Amine
6907 VH 032 - linker 12
VH 032-PEG2-amine
6464 VH 032 - linker 2
VH 032-PEG4-amine
6465 VH 032 - linker 3
VH 032-alkylC4-amine
6679 VH 032 - linker 4
VH 032-PEG3-CH2CH2COOH
6680 VH 032 - linker 5
VH 032-alkylC4-carboxylic acid
6684 VH 032 - linker 6
VH 032-PEG2-alkyne
6852 VH 032 - linker 7
VH 032-alkylC2-amine
6853 VH 032 - linker 8
VH 032-alkylC6-amine
6879 VH 032 - linker 9
VH 032-PEG1-amine
6909 VH 032 phenol - linker 1
VH 032 phenol-alkylC4-amine
6910 VH 032 phenol - linker 2
VH 032 phenol-alkylC6-amine

Literature for VHL Targeting Ligands Plus Linkers

Tocris offers the following scientific literature for VHL Targeting Ligands Plus Linkers to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.