Building Blocks |
|
Cat. No. | Product Name / Activity |
---|---|
6880 | VH 032 amide-alkylC10-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7106 | VH 032 amide-alkylC2-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
6852 | VH 032 amide-alkylC2-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7216 | VH 032 amide-alkylC3-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
7073 | VH 032 amide-alkylC3-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6680 | VH 032 amide-alkylC4-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
6465 | VH 032 amide-alkylC4-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7217 | VH 032 amide-alkylC5-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
6985 | VH 032 amide-alkylC5-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7867 | VH 032 amide-alkylC5-azide |
VHL ligand with alkylC5 linker and terminal azide for onward chemistry | |
7107 | VH 032 amide-alkylC6-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
6853 | VH 032 amide-alkylC6-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7925 | VH 032 amide-alkylC7-acid New |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
7074 | VH 032 amide-alkylC7-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7108 | VH 032 amide-alkylC8-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
6890 | VH 032 amide-alkylC8-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7404 | VH 032 amide-alkylC9-acid |
VHL ligand with alkyl linker and terminal acid for onward chemistry | |
7566 | VH 032 amide-alkylC9-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7104 | VH 032 amide-PEG1-acid |
VHL ligand with PEG linker and terminal acid for onward chemistry | |
6879 | VH 032 amide-PEG1-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
7214 | VH 032 amide-PEG2-acid |
VHL ligand with PEG linker and terminal acid for onward chemistry | |
6684 | VH 032 amide-PEG2-alkyne |
VHL ligand with PEG linker and terminal alkyne for onward chemistry | |
6907 | VH 032 amide-PEG2-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
6679 | VH 032 amide-PEG3-acid |
VHL ligand with PEG linker and terminal acid for onward chemistry | |
6463 | VH 032 amide-PEG3-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
7215 | VH 032 amide-PEG4-acid |
VHL ligand with PEG linker and terminal acid for onward chemistry | |
6464 | VH 032 amide-PEG4-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
7105 | VH 032 amide-PEG5-acid |
VHL ligand with PEG linker and terminal acid for onward chemistry | |
7568 | VH 032 amide-PEG6-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
6909 | VH 032 phenol-alkylC4-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6910 | VH 032 phenol-alkylC6-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7293 | VH 101 phenol-alkylC4-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
7294 | VH 101 phenol-alkylC6-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry |
Tocris offers the following scientific literature for VHL Targeting Ligands Plus Linkers to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia