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VH 032 amide-PEG2-acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
This product is provided for use in onward chemistry. Suitable solvents can be used.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
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Keywords: VH 032 amide-PEG2-acid, VH 032 amide-PEG2-acid supplier, VH032, amide-PEG2-acid, PROTACs, linker, Proteolysis, Targeting, Chimera, VHL, E3, ubiquitin, ligase, PEG2, polyethylene, glycol, conjugate, von-Hippel-Lindau, protein, ligand, building, blocks, components, (S,R,S)-AHPC-PEG2-COOH, Ligands, Plus, Linkers, 7214, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia