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|Cat. No.||Product Name / Activity|
|7689||(+)-JQ1 bump, acid functionalized|
|Functionalized BET bromodomain ligand; precursor for Tag Degraders|
|6588||(+)-JQ1 carboxylic acid|
|Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs|
|Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs|
Tocris offers the following scientific literature for Functionalized Warhead Ligands to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia