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VH 032 amide-PEG1-acid
Biological Activity for VH 032 amide-PEG1-acid
VH 032 amide-PEG1-acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for VH 032 amide-PEG1-acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for VH 032 amide-PEG1-acid
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VH 032 amide-PEG1-acid
References for VH 032 amide-PEG1-acid
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Keywords: VH 032 amide-PEG1-acid, VH 032 amide-PEG1-acid supplier, VH032, -, linker, 5, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, PEG1, polyethylene, glycol, conjugate, von-Hippel-Lindau, protein, ligand, building, blocks, components, Ligands, Plus, Linkers, 7104, Tocris Bioscience
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia