VH 032 phenol-alkylC4-amine

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Cat.No. 6909 - VH 032 phenol-alkylC4-amine | C28H41N5O5S.2HCl | CAS No. 2376990-26-8
Description: VHL ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names: VH 032 phenol - linker 1
Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for VH 032 phenol-alkylC4-amine

VH 032 phenol-alkylC4-amine is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 1

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 phenol-alkylC4-amine

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 phenol-alkylC4-amine

M. Wt 632.64
Formula C28H41N5O5S.2HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2376990-26-8
Smiles CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C)=O)C(C)(C)C)=O)=O)C(OCCCCN)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for VH 032 phenol-alkylC4-amine

Certificate of Analysis / Product Datasheet
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References for VH 032 phenol-alkylC4-amine

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Keywords: VH 032 phenol-alkylC4-amine, VH 032 phenol-alkylC4-amine supplier, PROTACs, von-Hippel-Lindau, protein, ligand, VHL, E3, ubiquitin, ligase, short, alkyl, linker, conjugate, VH032, targeted, degradation, TPD, building, blocks, 2376990-25-7, VH, 032, phenol, -, 1, Ligands, Plus, Linkers, 6909, Tocris Bioscience

Citations for VH 032 phenol-alkylC4-amine

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia