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VH 032 amide-alkylC7-amine
Biological Activity for VH 032 amide-alkylC7-amine
VH 032 amide-alkylC7-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for VH 032 amide-alkylC7-amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for VH 032 amide-alkylC7-amine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VH 032 amide-alkylC7-amine
References for VH 032 amide-alkylC7-amine
References are publications that support the biological activity of the product.
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Keywords: VH 032 amide-alkylC7-amine, VH 032 amide-alkylC7-amine supplier, VH032, amide-alkylC7-amine, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, alkyl, linker, conjugate, PROTAC, von-Hippel-Lindau, degrader, building, blocks, (S,R,S)-AHPC-C7-NH2, Ligands, Plus, Linkers, 7074, Tocris Bioscience
1 Citation for VH 032 amide-alkylC7-amine
Citations are publications that use Tocris products. Selected citations for VH 032 amide-alkylC7-amine include:
Jason W et al (2019) Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab 29 141-155.e9 PMID: 30174305
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia