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|Cat No||Product Name / Activity|
|6466||TC E3 5031|
|Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs|
|6628||TC E3 5032|
|Precursor to Pomalidomide-based PROTACs|
|6685||Thalidomide, propargyl New|
|Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs|
|6462||VH 032, amine hydrochloride|
|Functionalized VHL ligand for PROTACs|
|6683||VH 032, propargyl New|
|Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs|
Tocris offers the following scientific literature for Functionalized E3 Ligase Ligands to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.