Functionalized E3 Ligase Ligands
Ligands |
|
| Cat. No. | Product Name / Activity |
|---|---|
| 6466 | TC E3 5031 |
| Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs | |
| 6628 | TC E3 5032 |
| Precursor to Pomalidomide-based PROTACs | |
| 6685 | Thalidomide, propargyl |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | |
| 6462 | VH 032, amine hydrochloride |
| Functionalized VHL ligand for PROTACs | |
| 6683 | VH 032, propargyl |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | |
Controls |
|
| Cat. No. | Product Name / Activity |
| 6969 | cis VH 032, amine dihydrochloride New |
| Negative control for VH 032, amine (Cat. No. 6462) | |
Literature for Functionalized E3 Ligase Ligands
Tocris offers the following scientific literature for Functionalized E3 Ligase Ligands to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia
This poster discusses the generation of a toolbox of building blocks for the development of Degraders.
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