Functionalized E3 Ligase Ligands
Building Blocks |
|
| Cat. No. | Product Name / Activity |
|---|---|
| 6471 | A 410099.1, amine |
| Functionalized IAP ligand for PROTACs | |
| 7678 | 5-Amino-Thalidomide New |
| Cereblon ligand with amine on C5 for onward chemistry | |
| 7178 | LCL 161, phenol |
| Functionalized IAP ligand for PROTACs | |
| 7670 | Phenyl-glutarimide 4'-oxyacetic acid New |
| Functionalized cereblon ligand for PROTAC development | |
| 7328 | Photo-lenalidomide-acid |
| Functionalized photoswitchable cereblon ligand for Degraders | |
| 6628 | TC E3 5032 |
| Precursor to Pomalidomide-based PROTACs | |
| 7773 | tDHU, acid New |
| Functionalized cereblon ligand for PROTAC development | |
| 7456 | Thalidomide, 5'-fluoro New |
| Fluoro functionalized Thalidomide; cereblon ligand for PROTACs | |
| 6685 | Thalidomide, propargyl |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | |
| 6466 | Thalidomide-4-hydroxyacetate |
| Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs | |
| 6462 | VH 032, amine |
| Functionalized VHL ligand for PROTACs | |
| 6911 | VH 032, phenol |
| Hydroxyl functionalized VHL ligand | |
| 6683 | VH 032, propargyl |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | |
| 7758 | VH 101, acid New |
| VHL ligand, carboxylic acid functionalized at the benzylic position | |
| 6952 | VH 101, phenol |
| Hydroxyl functionalized VHL ligand | |
Controls |
|
| Cat. No. | Product Name / Activity |
| 6969 | cis VH 032, amine dihydrochloride |
| Negative control for VH 032, amine (Cat. No. 6462) | |
| 7716 | N-methylated pomalidomide New |
| Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control | |
Literature for Functionalized E3 Ligase Ligands
Tocris offers the following scientific literature for Functionalized E3 Ligase Ligands to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia
This poster discusses the generation of a toolbox of building blocks for the development of Degraders.
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