Functionalized E3 Ligase Ligands
Building Blocks |
|
| Cat. No. | Product Name / Activity |
|---|---|
| 6471 | A 410099.1, amine |
| Functionalized IAP ligand for PROTACs | |
| 7678 | 5-Amino-Thalidomide |
| Cereblon ligand with amine on C5 for onward chemistry | |
| 8066 | CST 530, Phenol |
| Functionalized IAP ligand for PROTACs® | |
| 8003 | EN67, phenol |
| UBE2D degrader building block | |
| 7178 | LCL 161, phenol |
| Functionalized IAP ligand for PROTACs | |
| 7634 | Me VH 032, amine |
| Amine functionalized VHL ligand for PROTAC® research | |
| 7858 | PD 4'-oxyacetic acid |
| Functionalized cereblon ligand for PROTAC development | |
| 7859 | PD 4'-piperazine |
| Stable cereblon ligand, for PROTAC synthesis | |
| 7729 | Phenyl-glutarimide 4'-piperazine |
| Piperazine-functionalized cereblon ligand for PROTAC development | |
| 7670 | Phenyl-glutarimide 4'-oxyacetic acid |
| Functionalized cereblon ligand for PROTAC development | |
| 7773 | tDHU, acid |
| Functionalized cereblon ligand for PROTAC development | |
| 7456 | Thalidomide, 5'-fluoro |
| Fluoro functionalized Thalidomide; cereblon ligand for PROTACs | |
| 6685 | Thalidomide, propargyl |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | |
| 6466 | Thalidomide-4-hydroxyacetate |
| Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs | |
| 7759 | UNC 1215, acid |
| Functionalized L3MBTL3 ligand for PROTACs | |
| 6462 | VH 032, amine |
| Functionalized VHL ligand for PROTACs | |
| 6911 | VH 032, phenol |
| Hydroxyl functionalized VHL ligand | |
| 6683 | VH 032, propargyl |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | |
| 7861 | VH 032, thiol |
| Functionalized VHL ligand for PROTAC® development | |
| 7758 | VH 101, acid |
| VHL ligand, carboxylic acid functionalized at the benzylic position | |
| 6952 | VH 101, phenol |
| Hydroxyl functionalized VHL ligand | |
| 7884 | VH 101, thiol |
| Thiol functionalized VHL ligand | |
| 8075 | VHF 543, amine New |
| DCAF1 WD40 ligand with terminal amine for onward chemistry | |
Controls |
|
| Cat. No. | Product Name / Activity |
| 6969 | cis VH 032, amine dihydrochloride |
| Negative control for VH 032, amine (Cat. No. 6462) | |
| 7716 | N-methylated pomalidomide |
| Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control | |
Literature for Functionalized E3 Ligase Ligands
Tocris offers the following scientific literature for Functionalized E3 Ligase Ligands to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia
This poster discusses the generation of a toolbox of building blocks for the development of Degraders.
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