Building Blocks |
|
Cat. No. | Product Name / Activity |
---|---|
6471 | A 410099.1, amine |
Functionalized IAP ligand for PROTACs | |
7178 | LCL 161, phenol New |
Functionalized IAP ligand for PROTACs | |
6466 | TC E3 5031 |
Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs | |
6628 | TC E3 5032 |
Precursor to Pomalidomide-based PROTACs | |
6685 | Thalidomide, propargyl |
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | |
6462 | VH 032, amine |
Functionalized VHL ligand for PROTACs | |
6911 | VH 032, phenol |
Hydroxyl functionalized VHL ligand | |
6683 | VH 032, propargyl |
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | |
6952 | VH 101, phenol |
Hydroxyl functionalized VHL ligand | |
Controls |
|
Cat. No. | Product Name / Activity |
6969 | cis VH 032, amine dihydrochloride |
Negative control for VH 032, amine (Cat. No. 6462) |
Tocris offers the following scientific literature for Functionalized E3 Ligase Ligands to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia