Trk Receptors

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCγ signaling pathways. Four members of the Trk family have been identified.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4456 Amitriptyline hydrochloride
TrkA/B agonist; also a serotonin and noradrenaline uptake inhibitor
2837 BDNF (human)
Activates TrkB and p75 receptors
3826 7,8-Dihydroxyflavone
TrkB agonist
5961 HIOC
Selective TrkB receptor agonist; neuroprotectant
4607 LM 22A4
Potent TrkB agonist

Antagonists

Cat No Product Name / Activity
4781 ANA 12
TrkB receptor antagonist
5062 Cyclotraxin B
TrkB receptor antagonist

Inhibitors

Cat No Product Name / Activity
2617 AG 879
TrkA inhibitor
4559 GNF 5837
Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
2238 GW 441756
Potent, selective TrkA inhibitor
3395 Lestaurtinib
TrkA, JAK2 and FLT3 inhibitor; also inhibits AurA and AurB
6115 PF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted

Activators

Cat No Product Name / Activity
1819 Demethylasterriquinone B1
Trk receptor activator; also selective insulin RTK activator

Other

Cat No Product Name / Activity
5046 LM11A 31 dihydrochloride
Nonpeptide p75NTR ligand; neuroprotective
2087 NTR 368
p75NTR fragment; induces apoptosis
5101 PD 90780
Inhibits NGF binding to p75NTR
2272 Ro 08-2750
Inhibits NGF binding to p75NTR and TrkA
3051 TLQP 21
VGF-derived peptide

Trk (tropomyosin-related kinase or neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCγ signaling pathways. There are four members of the Trk family: TrkA, TrkB, TrkC and a related p75NTR receptor. p75NTR lacks tyrosine kinase activity and signals via NF-κB activation.

Each family member binds different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons, as well as in control of gene expression of enzymes involved in neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors with high affinity and retains low affinity to the mature cleaved forms.

TrkA was originally identified as an oncogene, as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

External sources of pharmacological information for Trk Receptors :

    Literature for Trk Receptors

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
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    Pain Poster

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    Parkinson's Poster

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    Trk Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    TrkA Human NTRK1 NM_002529 Q9UIU7
    Mouse Ntrk1 NM_001033124 Q3UFB7
    Rat Ntrk1 NM_021589 Q9JIW7
    TrkB Human NTRK2 NM_001018064 Q16620
    Mouse Ntrk2 NM_008745 P15209
    Rat Ntrk2 NM_012731 Q63604
    TrkC Human NTRK3 NM_002530 Q16288
    Mouse Ntrk3 NM_182809 Q6VNS1
    Rat Ntrk3 NM_019248 Q03351
    p75NTR Human NGFR NM_002507 P08138
    Mouse Ngfr NM_033217 Q9Z0W1
    Rat Ngfr NM_012610 Q62777