Ro 08-2750

Pricing Availability Delivery Time Qty
Cat.No. 2272 - Ro 08-2750 | C13H10N4O3 | CAS No. 37854-59-4
Description: Inhibits NGF binding to p75NTR and TrkA
Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells.

Technical Data

M. Wt 270.24
Formula C13H10N4O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 37854-59-4
PubChem ID 17756791
InChI Key JDEMVNYMYPJJIM-UHFFFAOYSA-N
Smiles CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 13.51 50
DMSO 2.7 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Niederhauser et al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263 PMID: 10900073

Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301 PMID: 15060526


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Keywords: Ro 08-2750, supplier, inhibitors, inhibits, NGF, binding, p75NTR, TrkA, Neurotrophin, Receptors, p75, Trk, Receptor, Tyrosine, Kinases, RTKs, Ro08-2750, Trk, Receptors, Tocris Bioscience

Citations for Ro 08-2750

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