GW 441756

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Cat.No. 2238 - GW 441756 | C17H13N3O | CAS No. 504433-23-2
Description: Potent, selective TrkA inhibitor
Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 275.31
Formula C17H13N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 504433-23-2
PubChem ID 16219401
InChI Key NXNQLECPAXXYTR-UHFFFAOYSA-N
Smiles CN1C=C(C=C2C(=O)NC3=CC=CN=C23)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.13 15

Preparing Stock Solutions

The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wood et al (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 14 953 PMID: 15013000


If you know of a relevant reference for GW 441756, please let us know.

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Keywords: Potent selective TrkA inhibitors inhibits Neurotrophin Receptors Receptor Tyrosine Kinases RTKs GW441756 GlaxoSmithKline GSK Trk Receptors

3 Citations for GW 441756

Citations are publications that use Tocris products. Selected citations for GW 441756 include:

Edwards et al (2011) Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst 103 1162 PMID: 21771732

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Oncotarget 12 109 PMID: 26656090

Lawn et al (2015) Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. Nat Chem Biol 290 3814 PMID: 25538243


Do you know of a great paper that uses GW 441756 from Tocris? If so please let us know.

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Pathways for GW 441756

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